• Therapeutic heart regeneration
  • Stem cell technologies and phenotypic assays
  • Development of ‚molecular tools' for pharmacology and chemical biology applications
  • Study of developmental signaling pathway modulators

 

Research in the Schade lab is devoted to drug development at the interface of stem cell biology and medicinal chemistry. We make use of various bioanalytical methods to identify and characterize novel small molecules for applications in ‚Regenerative Medicine' with a particular focus on restoring heart tissue function after myocardial infarction. Our high-throughput-compatible phenotypic assays furnish new potential drug candidates that are systematically optimized in an iterative process of design, organic synthesis and structure-activity relationship analysis. Moreover, such compounds are also employed and further developed as ‚molecular tools' to study their underlying mode-of-action. Our main attention is currently centred on modulators of the TGFß superfamily of ligands, the Wnt/ß-Catenin signaling pathway as well as stimulators of cardiomyocyte proliferation.