All Publications

Peer-review Artikel (peer-review articles):

Scherließ, R., Future of nanomedicines for treating respiratory diseases. Expert Opinion Drug Delivery 16 (2019) 59-68

Hildebrandt, C., Gopireddy, S.R., Scherließ, R. and Urbanetz, N.A., Assessment of material and process attributes' influence on tablet quality using a QbD and DEM combined approach. Powder Technology 345 (2019) 390-404

Wöll, S., Bachran, C., Schiller, S., Schröder, M., Conrad, L., Scherließ, R. and Swee, L.K., Sortagging of liposomes with a murine-CD11b-specific VHH increases in vitro and in vivo targeting specificity of myeloid cells International Journal of Pharmaceutics  134 (2019) 190-198

Scherließ, R. and Etschmann, C., DPI formulations for high dose applications - challenges and opportunities. International Journal of Pharmaceutics 548 (2018) 49-53

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., Powder Flow Analysis: a Simple Method to Indicate the Ideal Amount of Lactose Fines in Dry Powder Inhaler Formulations. Int J Pharm 535 (2018) 59-67

Hildebrandt, C., Gopireddy, S., Scherließ, R. and Urbanetz, N.A., Numerical analysis of the die filling process within a pharmaceutical tableting machine. Chemie Ingenieur Technik 90 (2018) 483-492

Hildebrandt, C., Gopireddy, S.R., Scherließ, R., Urbanetz, N.A., 2018. Simulation of particle size segregation in a pharmaceutical tablet press lab-scale gravity feeder. Advanced Powder Technology 29, 765-780

Heidland, J., Helm, O., Lettau, M., Winter, E., Sebens, S. and Scherließ, R., Nano-in-microparticles for Dry Powder Vaccination – Nasal Application and Uptake in Immune Competent Cells, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 339-344

Jüptner, A., Hellfritzsch, M., Kaj, C., Vimont, A., Sarrailh, S., Grosjean, B., Williams, G. and Scherließ, R., Spray Dried Formulations for Nasal Applications – Challenges and Opportunities in Filling and Drug Delivery, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 345-348

Kobler, M., Hertel, M., Hauptstein, S., Scherließ, R. and Steckel, H., Influence of storage conditions on micronized lactose and the resulting ternary dry powder inhaler formulations, in: Dalby, R.e.a. (Ed.), Respiratory Drug Delivery. Davies Healthcare International Publishing, Tucson, AZ, USA (2018) 447-450

Rhein, N., Birk, G. and Scherließ, R., Influence of Drug Concentration on Dry Powder Inhaler Formulations Based on a Mannitol and a Lactose Carrier System, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 349-354

Tanabe, S., Nakagawa, H., Watanabe, T., Minami, H., Urbanetz, N.A. and Scherließ, R., Selection of a round convex tablet shape that mitigates the risk of chipping and capping based on systematic evaluation. European Journal of Pharmaceutical Sciences 120 (2018) 212-221

Wöll, S., Schiller, S., Bachran, C., Swee, L.K. and Scherließ, R., Pentaglycine lipid derivates – rp-HPLC-analytics for bioorthogonal anchor molecules in targeted, multiple-composite liposomal drug delivery systems. International Journal of Pharmaceutics  547 (2018) 602-610

Rhein, N., Birk, G. and Scherließ, R., Spray-granulated mannitol as a viable alternative for lactose in DPI formulations: Preparation of ordered mixtures and storage stability. Inhalation (2018) 17-23

Wöll, S., Conrad, L., Swee, L.K., Schiller, S., Bachran, C., Schröder, M. and Scherließ, R., Sortaggable liposomes: Evaluation of reaction conditions for single-domain antibody conjugation by Sortase A and targeting of CD11b+ myeloid cells. European Journal of Pharmaceutics and Biopharmaceutics 133 (2018) 138-150

Saarinen, J., Gütter, F., Lindman, M., Agopov, M., Fraser-Miller, S.J., Scherließ, R., Jokitalo, E., Santos, H.A., Peltonen, L., Isomäki, A. and Strachan, C., Cell-Nanoparticle Interactions at Sub(nanometer) Resolution Analysed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering. Biotechnology Journal (2018) 1800413

Renner, N., Steckel, H., Urbanetz, N. and Scherließ, R., Nano- and Microstructured model carrier surfaces to alter dry powder inhaler performance. Int J Pharm 518 (2017) 20-28

Mönckedieck, M., Kamplade, J., Fakner, P., Urbanetz, N.A., Walzel, P., Steckel, H. and Scherließ, R., Dry powder inhaler performance of spray dried mannitol with tailored surface morphologies as carrier and salbutamol sulphate. Int J Pharm 524 (2017) 351-363

Armbruster, M., Mönckedieck, M., Scherließ, R., Daniels, R. and Wahl, M.A., Birch bark dry extract by supercritical fluid technology: extract characterisation and use for stabilisation of semisolid systems. ACS Applied Sciences 7 (2017)

Mönckedieck, M., Kamplade, J., Fakner, P., Urbanetz, N.A., Walzel, P., Steckel, H. and Scherließ, R., Spray drying of mannitol carrier particles with defined morphology and flow characteristics for dry powder inhalation. Drying Technology 35 (2017) http://dx.doi.org/10.1080/07373937.2017.1281291

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., An Easy Method to Indicate the Ideal Amount of Lactose Fines in Dry Powder Inhaler Formulations, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 189-193

Rhein, N., Birk, G. and Scherließ, R., Storage Stability of a Novel Mannitol Carrier in Dry Powder Inhalation Formulation, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 201-205

Renner, N., Steckel, H., Urbanetz, N. and Scherließ, R., Tailoring the Surface Topography of a Model Carrier to alter Dry Powder Inhaler Performance, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 195-199

Albrecht, S., Scherließ, R., Baehr, M., Goerke, A. and Langebrake, C., Umstellung häufig verordneter Kapselrezepturen in der Pädiatrie und Neonatologie auf flüssige Oralia im Krankenhaus. Krankenhauspharmazie 38 (2017) 459-468 (author prize 2018)

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., The Influence of High Shear Mixing on Ternary Dry Powder Inhaler Formulations. Int J Pharm 534 (2017) 242-250

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H., Scherließ, R., The influence of lactose fines in dry powder inhaler formulations. Inhalation 11 (2017) 22-26

Hildebrandt, C., Gopireddy, S.R., Fritsch, A.K., Profitlich, T., Scherließ, R. and Urbanetz, N.A., Evaluation and prediction of powder flowability in pharmaceutical tableting. Pharmaceutical Development and Technology 13 (2017) 1-13

Scherließ, R., Inhalativa – Arzneiformen zur lokalen und systemischen Gabe/ Inhaled dosage forms –formulations for local and systemic delivery, Pharmacon, 02/16 (2016)

Scherließ, R., Exploring the potential of mannitol as an alternative to lactose in dry powder inhalation, Inhalation (2016) 30-32

Trows, S. and Scherließ, R., Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug Powder Technology 292 (2016) 223-231

Rietscher, R., Schröder, M., Janke, J., Czaplewska, J.A., Gottschaldt, M., Scherließ, R., Hanefeld, A., Schubert, U.S., Schneider, M., Knolle, P. and Lehr, C.-M., Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity. EJPB 102 (2016) 20-31

Hertel, M., Littringer, E.M., Hauptstein, S., Dogru, M., Schwarz, E., Scherließ, R. and Steckel, H., The influence of high shear mixing parameters on the performance of ternary dry powder inhaler formulations, Respiratory Drug Delivery 2016, Phoenix, AZ, USA (2016)

Baleeiro, R.B., Schweinlin, M., Rietscher, R., Diedrich, A., Czaplewska, J.A., Metzger, M., Lehr, C.M., Scherließ, R., Hanefeld, A., Gottschaldt, M. and Walden, P., Nanoparticle-Based Mucosal Vaccines Targeting Tumor-Associated Antigens to Human Dendritic Cells. Journal of Biomedical Nanotechnology 12 (2016) 1-17

Hittinger, M., Janke, J., Huwer, H., Scherließ, R., Schneider-Daum, N. and Lehr, C.-M., Autologous co-culture of Primary Human Alveolar Macrophages and Epithelial Cells for Investigating Aerosol Medicines. Part I: Model Characterisation. Altern. Lab Anim. 44 (2016) 337-347

Dogru, M., Hertel, M., Littringer, E.M., Schwarz, E., Scherließ, R. and Steckel, H., Investigating the effect of mixing parameters and mixer type on the performance of ternary dry powder inhaler formulations, in: Dalby, R.et al. (Ed.), RDD Asia 2016. Davies Healthcare International Publishing, Goa, India (2016) 237-242

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S. and Hook, S., First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice. Int J Pharm 479 (2015) 408-415

Scherließ, R., Diedrich, A., Ebensen, T., Guzmán, C.A., Wolf, M. and Hanefeld, A., Chitosan nanoparticulate formulation for pulmonary vaccination – formulation and in vivo proof of concept, RDD Europe. Dalby, R. et al., Antibes (2015)

Mönckedieck, M., Kamplade, J., Fakner, P., Scherließ, R., Walzel, P. and Steckel, H., The Impact of Particle Shape on the Dry Powder Inhaler Performance of Spray Dried Mannitol Carrier Particles, in: Dalby, R.N. (Ed.), RDD Europe, Antibes (2015)

Baleeiro, R.B., Rietscher, R., Diedrich, A., Czaplewska, J.A., Lehr, C.M., Scherließ, R., Hanefeld, A., Gottschaldt, M. and Walden, P., Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells. OncoImmunology 4 (2015) e1047585

Müller, T., Scherließ, R., Schiewe, J., Smal, R., Weiler, C. and Steckel, H., Applicability of a one-step DVS method for the determination of amorphous amounts for further different hydrophilic and hydrophobic drugs. European Journal of Pharmaceutics and Biopharmaceutics 94 (2015) 333-341

Ajmera, A. and Scherließ, R., Stabilisation of proteins via mixtures of amino acids during spray drying. Int J Pharm, 463 (2014) 98-107

Scherließ, R., Ajmera, A., Dennis, M., Carroll, M., Altrichter, J., Silman, N., Scholz, M., Kemter, K., Marriott, A., Induction of protective immunity against H1N1 influenza A with spray-dried and electron-beam sterilised vaccines in non-human primates. Vaccine 32 (2014) 2231-2240

Scherließ, R., Trows, S. and Buske, S., Overcoming challenges of inhaled vaccines through intelligent particle engineering, Inhalation, 6 (2013) 8-14

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S. and Hook, S., Evaluation of impact of nasal dry powder vaccine formulations on uptake and activation by dendritic cells. in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery Europe (2013) 279-283

Scherließ, R., Buske, S., Young, K., Weber, B., Rades, T. and Hook, S., In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. Vaccine 31 (2013) 4812-4819

Scherließ, R., Buske, S., Dry powder nanoparticulate formulations for mucosal vaccination, in Nanoformulation, edited by Tiddy G, Tan RB. Singapore, RSC Publishing (2012) 104-112

Trows, S. and Scherließ, R., Preparation and Characterization of Dry Powder Agarose Nano-in-Microparticles for Nasal Vaccination, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2012) 2, 491-496

Scherließ, R., Influences of Conditioning and Application Device on in vitro Nasal Deposition of a Dry Powder Vaccine Formulation, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2012) 2, 473-478

Zarie, E.S., Kaidas, V., Gedamu, D., Mishra, Y.K., Adelung, R., Furkert, F.H., Scherließ, R., Steckel, H. and Grössner-Schreiber, B., Solvent free fabrication of micro and nanostructured drug coatings by thermal evaporation for controlled release and increased effects, PLoS one (2012) 7(8), e40746

Scherließ, R., The MTT assay as tool to evaluate and compare excipient toxicity in vitro on respiratory epithelial cells, Int J Pharm, 411 (2011) 98-105

Scherließ, R. and Trows, S., Novel Formulation Concept for Particulate Uptake of Vaccines via the Nasal Associated Lymphoid Tissue, Procedia in Vaccinology, 4 (2011) 113-119

Scherließ, R. and Trows, S., Characterization of Nasal Deposition and Post-Nasal Fraction of a Model Vaccine Protein Formulation, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery Europe 2011 (2011) 321-325

Scherließ, R., In vitro particle deposition in the nasal cavity, Inhalation, 5 (2011) 14-18

Scherließ, R., Delivery of antigens used for vaccination - recent advances and challenges, Therapeutic Delivery 2 (2011) 1351-1368

Westmeier, R., In vitro Screening Test for Respiratory Toxicity, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2010) 529-533

Westmeier, R., Novel Formulation Concept for Nasal Deposition of Dry Powder Vaccines, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2010) 523-527

Westmeier, R. and Steckel, H., Zum Stellenwert der fixen Kombination von ß2-Sympathomimetika und Glucocorticoiden in der Asthmatherapie, PZ Prisma, 16 (2009) 13-24

Westmeier, R. and Steckel, H., Combination particles of Salmeterol xinafoate and Fluticasone propionate: formulation and aerodynamic assessment, Journal of Pharmaceutical Sciences, 97 (2008) 2299-2310

Heydenreich, A. V., Westmeier, R., Pedersen, N., Poulsen, H. S. and Kristensen, H. G., Preparation and purification of cationic solid lipid nanospheres - effects on particle size, physical stability and cell toxicity, Int J Pharm, 254 (2003) 83-87