Publikationen

LATEST JOURNAL ARTICLES 2020

Hertel, N., Birk, G. and Scherließ, R., Particle engineered mannitol for carrier-based inhalation – a serious alternative? International Journal of Pharmaceutics 577 (2020) 118901
https://doi.org/10.1016/j.ijpharm.2019.118901  

Penate Medina, T., Kraas, E.J., Luo, K., Humbert, J., Zhu, H., Mertens, F., Gerle, M., Rochweder, A., Damoaha, C., Will, O., Acil, Y., Kairemo, K., Glüer, C.C., Scherließ, R., Sebens, S. and Penate Medina, O., Utilizing ICG spectroscopical properties for real-time nanoparticle release quantification in vitro and in vivo in imaging setups Current Pharmaceutical Design (2020)
https://doi.org/10.2174/1381612826666200318170849

Jüptner, A. and Scherließ, R., Spray dried formulations for inhalation – meaningful characterisation of powder properties. Pharmaceutics Special Issue: Drying in Pharmaceutics 12 (2020)
https://doi.org/10.3390/pharmaceutics12010014

Scherließ, R., Nasal formulations for drug administration and characterisation of nasal preparations in drug delivery. Therapeutic Delivery (2020)
https://doi.org/10.4155/tde-2019-0086

Forbes, B., Bommer, R., Goole, J., Hellfritzsch, M., de Kruijf, W., Lambert, P., Caivano, G., Regard, A., Schiaretti, F., Trenkel, M., Vecellio, L., Williams, G., Sonvico, F. and Scherließ, R., A Consensus Research Agenda for Optimising Nasal Drug Delivery. Expert Opinion on Drug Delivery (2020)
https://doi.org/10.1080/17425247.17422020.11714589


ALL PEER REVIEW ARTICLES

2019


Alopaeus, J.F., Hellfritzsch, M., Gutowski, T., Scherließ, R., Almeida, A., Sarmento, B., Škalko-Basnet, N. and Tho, I., Mucoadhesive buccal films based on a graft co-polymer - A mucin-retentive hydrogel scaffold. EJPS 142 (2019)
https://doi.org/10.1016/j.ejps.2019.105142

Hellfritzsch, M. and Scherließ, R., Mucosal Vaccination via the Respiratory Tract. Pharmaceutics 11 (2019)
https://doi.org/10.3390/pharmaceutics11080375

Scherließ, R. and Knop-Schneickert, E., Tauglichkeit der Arzneiformen für Manipulationen - Teilbarkeit und Sondengängigkeit. PZ Prisma 26 (2019) 89-97

Tanabe, S., Gopireddy, S., Minami, H., Ando, S., Urbanetz, N.A. and Scherließ, R., Influence of particle size and blender size on blending performance of bi-component granular mixing: A DEM and experimental study. European Journal of Pharmaceutical Sciences 134 (2019) 205-218
https://doi.org/10.1016/j.ejps.2019.04.024

Wingrove, J., Swedrowska, M., Scherließ, R., Parry, M., Ramjeeawon, M., Taylor, D., Gauthier, G., Brown, L., Amiel, S., Zelaya, F. and Forbes, B., Characterisation of nasal devices for delivery of insulin to the brain and evaluation in humans using functional magnetic resonance imaging. Journal of Controlled Release 302 (2019) 140-147
https://doi.org/10.1016/j.jconrel.2019.03.032

Hildebrandt, C., Gopireddy, S.R., Fritsch, A.K., Profitlich, T., Scherließ, R. and Urbanetz, N.A., Evaluation and prediction of powder flowability in pharmaceutical tableting. Pharmaceutical Development and Technology 24 (2019) 35-47
https://doi.org/10.1080/10837450.2017.1412462

Wöll, S., Dickgiesser, S., Rasche, N., Schiller, S. and Scherließ, R., Sortagged anti-EGFR immunoliposomes exhibit increased cytotoxicity on target cell. European Journal of Pharmaceutics and Biopharmaceutics 136 (2019) 203-212
https://doi.org/10.1016/j.ejpb.2019.01.020

Scherließ, R., Future of nanomedicines for treating respiratory diseases. Expert Opinion Drug Delivery 16 (2019) 59-68
https://doi.org/10.1080/17425247.2019.1553955

Hildebrandt, C., Gopireddy, S., Scherließ, R. and Urbanetz, N.A., Investigation of powder flow within a pharmaceutical tablet press force feeder - a DEM approach. Powder Technology 345 (2019) 616-632
https://doi.org/10.1016/j.powtec.2019.01.040

Hildebrandt, C., Gopireddy, S.R., Scherließ, R. and Urbanetz, N.A., Assessment of material and process attributes' influence on tablet quality using a QbD and DEM combined approach. Powder Technology 345 (2019) 390-404
https://doi.org/10.1016/j.powtec.2019.01.015

Wöll, S., Bachran, C., Schiller, S., Schröder, M., Conrad, L., Scherließ, R. and Swee, L.K., Sortagging of liposomes with a murine-CD11b-specific VHH increases in vitro and in vivo targeting specificity of myeloid cells. International Journal of Pharmaceutics  134 (2019) 190-198
https://doi.org/10.1016/j.ejpb.2018.11.014

2018


Scherließ, R. and Etschmann, C., DPI formulations for high dose applications - challenges and opportunities. International Journal of Pharmaceutics 548 (2018) 49-53
https://doi.org/10.1016/j.ijpharm.2018.06.038

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., Powder Flow Analysis: a Simple Method to Indicate the Ideal Amount of Lactose Fines in Dry Powder Inhaler Formulations. International Journal of Pharmaceutics 535 (2018) 59-67
https://doi.org/10.1016/j.ijpharm.2017.10.052

Heidland, J., Helm, O., Lettau, M., Winter, E., Sebens, S. and Scherließ, R., Nano-in-microparticles for Dry Powder Vaccination – Nasal Application and Uptake in Immune Competent Cells, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 339-344

Jüptner, A., Hellfritzsch, M., Kaj, C., Vimont, A., Sarrailh, S., Grosjean, B., Williams, G. and Scherließ, R., Spray Dried Formulations for Nasal Applications – Challenges and Opportunities in Filling and Drug Delivery, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 345-348

Kobler, M., Hertel, M., Hauptstein, S., Scherließ, R. and Steckel, H., Influence of storage conditions on micronized lactose and the resulting ternary dry powder inhaler formulations, in: Dalby, R.e.a. (Ed.), Respiratory Drug Delivery. Davies Healthcare International Publishing, Tucson, AZ, USA (2018) 447-450

Rhein, N., Birk, G. and Scherließ, R., Influence of Drug Concentration on Dry Powder Inhaler Formulations Based on a Mannitol and a Lactose Carrier System, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 349-354

Hildebrandt, C., Gopireddy, S., Scherließ, R. and Urbanetz, N.A., Numerical analysis of the die filling process within a pharmaceutical tableting machine. Chemie Ingenieur Technik 90 (2018) 483-492
https://doi.org/10.1002/cite.201700114

Hildebrandt, C., Gopireddy, S.R., Scherließ, R., Urbanetz, N.A., Simulation of particle size segregation in a pharmaceutical tablet press lab-scale gravity feeder. Advanced Powder Technology 29 (2018) 765-780
https://doi.org/10.1016/j.apt.2017.12.019

Tanabe, S., Nakagawa, H., Watanabe, T., Minami, H., Urbanetz, N.A. and Scherließ, R., Selection of a round convex tablet shape that mitigates the risk of chipping and capping based on systematic evaluation. European Journal of Pharmaceutical Sciences 120 (2018) 212-221
https://doi.org/10.1016/j.ejps.2018.05.008

Wöll, S., Schiller, S., Bachran, C., Swee, L.K. and Scherließ, R., Pentaglycine lipid derivates – rp-HPLC-analytics for bioorthogonal anchor molecules in targeted, multiple-composite liposomal drug delivery systems. International Journal of Pharmaceutics  547 (2018) 602-610
https://doi.org/10.1016/j.ijpharm.2018.05.052

Rhein, N., Birk, G. and Scherließ, R., Spray-granulated mannitol as a viable alternative for lactose in DPI formulations: Preparation of ordered mixtures and storage stability. Inhalation (2018) Dec17-23
https://www.inhalationmag.com/article/

Wöll, S., Conrad, L., Swee, L.K., Schiller, S., Bachran, C., Schröder, M. and Scherließ, R., Sortaggable liposomes: Evaluation of reaction conditions for single-domain antibody conjugation by Sortase A and targeting of CD11b+ myeloid cells. European Journal of Pharmaceutics and Biopharmaceutics 133 (2018) 138-150
https://doi.org/10.1016/j.ejpb.2018.09.017

Saarinen, J., Gütter, F., Lindman, M., Agopov, M., Fraser-Miller, S.J., Scherließ, R., Jokitalo, E., Santos, H.A., Peltonen, L., Isomäki, A. and Strachan, C., Cell-Nanoparticle Interactions at Sub(nanometer) Resolution Analysed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering. Biotechnology Journal (2018) 1800413
https://doi.org/10.1002/biot.201800413

2017


Renner, N., Steckel, H., Urbanetz, N. and Scherließ, R., Nano- and Microstructured model carrier surfaces to alter dry powder inhaler performance. Int J Pharm 518 (2017) 20-28
Mönckedieck, M., Kamplade, J., Fakner, P., Urbanetz, N.A., Walzel, P., Steckel, H. and Scherließ, R., Dry powder inhaler performance of spray dried mannitol with tailored surface morphologies as carrier and salbutamol sulphate. Int J Pharm 524 (2017) 351-363

Armbruster, M., Mönckedieck, M., Scherließ, R., Daniels, R. and Wahl, M.A., Birch bark dry extract by supercritical fluid technology: extract characterisation and use for stabilisation of semisolid systems. ACS Applied Sciences 7 (2017)

Mönckedieck, M., Kamplade, J., Fakner, P., Urbanetz, N.A., Walzel, P., Steckel, H. and Scherließ, R., Spray drying of mannitol carrier particles with defined morphology and flow characteristics for dry powder inhalation. Drying Technology 35 (2017)
http://dx.doi.org/10.1080/07373937.2017.1281291

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., An Easy Method to Indicate the Ideal Amount of Lactose Fines in Dry Powder Inhaler Formulations, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 189-193

Rhein, N., Birk, G. and Scherließ, R., Storage Stability of a Novel Mannitol Carrier in Dry Powder Inhalation Formulation, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 201-205

Renner, N., Steckel, H., Urbanetz, N. and Scherließ, R., Tailoring the Surface Topography of a Model Carrier to alter Dry Powder Inhaler Performance, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 195-199

Albrecht, S., Scherließ, R., Baehr, M., Goerke, A. and Langebrake, C., Umstellung häufig verordneter Kapselrezepturen in der Pädiatrie und Neonatologie auf flüssige Oralia im Krankenhaus. Krankenhauspharmazie 38 (2017) 459-468 (author prize 2018)

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., The Influence of High Shear Mixing on Ternary Dry Powder Inhaler Formulations. Int J Pharm 534 (2017) 242-250

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H., Scherließ, R., The influence of lactose fines in dry powder inhaler formulations. Inhalation 11 (2017) 22-26

2016


Scherließ, R., Inhalativa – Arzneiformen zur lokalen und systemischen Gabe/ Inhaled dosage forms –formulations for local and systemic delivery, Pharmacon, 02/16 (2016)

Scherließ, R., Exploring the potential of mannitol as an alternative to lactose in dry powder inhalation, Inhalation (2016) 30-32

Trows, S. and Scherließ, R., Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug Powder Technology 292 (2016) 223-231

Rietscher, R., Schröder, M., Janke, J., Czaplewska, J.A., Gottschaldt, M., Scherließ, R., Hanefeld, A., Schubert, U.S., Schneider, M., Knolle, P. and Lehr, C.-M., Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity. EJPB 102 (2016) 20-31

Hertel, M., Littringer, E.M., Hauptstein, S., Dogru, M., Schwarz, E., Scherließ, R. and Steckel, H., The influence of high shear mixing parameters on the performance of ternary dry powder inhaler formulations, Respiratory Drug Delivery 2016, Phoenix, AZ, USA (2016)

Baleeiro, R.B., Schweinlin, M., Rietscher, R., Diedrich, A., Czaplewska, J.A., Metzger, M., Lehr, C.M., Scherließ, R., Hanefeld, A., Gottschaldt, M. and Walden, P., Nanoparticle-Based Mucosal Vaccines Targeting Tumor-Associated Antigens to Human Dendritic Cells. Journal of Biomedical Nanotechnology 12 (2016) 1-17

Hittinger, M., Janke, J., Huwer, H., Scherließ, R., Schneider-Daum, N. and Lehr, C.-M., Autologous co-culture of Primary Human Alveolar Macrophages and Epithelial Cells for Investigating Aerosol Medicines. Part I: Model Characterisation. Altern. Lab Anim. 44 (2016) 337-347

Dogru, M., Hertel, M., Littringer, E.M., Schwarz, E., Scherließ, R. and Steckel, H., Investigating the effect of mixing parameters and mixer type on the performance of ternary dry powder inhaler formulations, in: Dalby, R.et al. (Ed.), RDD Asia 2016. Davies Healthcare International Publishing, Goa, India (2016) 237-242
2015
Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S. and Hook, S., First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice. Int J Pharm 479 (2015) 408-415

Scherließ, R., Diedrich, A., Ebensen, T., Guzmán, C.A., Wolf, M. and Hanefeld, A., Chitosan nanoparticulate formulation for pulmonary vaccination – formulation and in vivo proof of concept, RDD Europe. Dalby, R. et al., Antibes (2015)

Mönckedieck, M., Kamplade, J., Fakner, P., Scherließ, R., Walzel, P. and Steckel, H., The Impact of Particle Shape on the Dry Powder Inhaler Performance of Spray Dried Mannitol Carrier Particles, in: Dalby, R.N. (Ed.), RDD Europe, Antibes (2015)

Baleeiro, R.B., Rietscher, R., Diedrich, A., Czaplewska, J.A., Lehr, C.M., Scherließ, R., Hanefeld, A., Gottschaldt, M. and Walden, P., Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells. OncoImmunology 4 (2015) e1047585

Müller, T., Scherließ, R., Schiewe, J., Smal, R., Weiler, C. and Steckel, H., Applicability of a one-step DVS method for the determination of amorphous amounts for further different hydrophilic and hydrophobic drugs. European Journal of Pharmaceutics and Biopharmaceutics 94 (2015) 333-341

2014


Ajmera, A. and Scherließ, R., Stabilisation of proteins via mixtures of amino acids during spray drying. Int J Pharm, 463 (2014) 98-107

Scherließ, R., Ajmera, A., Dennis, M., Carroll, M., Altrichter, J., Silman, N., Scholz, M., Kemter, K., Marriott, A., Induction of protective immunity against H1N1 influenza A with spray-dried and electron-beam sterilised vaccines in non-human primates. Vaccine 32 (2014) 2231-2240

2013


Scherließ, R., Trows, S. and Buske, S., Overcoming challenges of inhaled vaccines through intelligent particle engineering, Inhalation, 6 (2013) 8-14

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S. and Hook, S., Evaluation of impact of nasal dry powder vaccine formulations on uptake and activation by dendritic cells. in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery Europe (2013) 279-283

Scherließ, R., Buske, S., Young, K., Weber, B., Rades, T. and Hook, S., In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. Vaccine 31 (2013) 4812-4819

2012


Scherließ, R., Buske, S., Dry powder nanoparticulate formulations for mucosal vaccination, in Nanoformulation, edited by Tiddy G, Tan RB. Singapore, RSC Publishing (2012) 104-112

Trows, S. and Scherließ, R., Preparation and Characterization of Dry Powder Agarose Nano-in-Microparticles for Nasal Vaccination, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2012) 2, 491-496

Scherließ, R., Influences of Conditioning and Application Device on in vitro Nasal Deposition of a Dry Powder Vaccine Formulation, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2012) 2, 473-478

Zarie, E.S., Kaidas, V., Gedamu, D., Mishra, Y.K., Adelung, R., Furkert, F.H., Scherließ, R., Steckel, H. and Grössner-Schreiber, B., Solvent free fabrication of micro and nanostructured drug coatings by thermal evaporation for controlled release and increased effects, PLoS one (2012) 7(8), e40746

2011


Scherließ, R., The MTT assay as tool to evaluate and compare excipient toxicity in vitro on respiratory epithelial cells, Int J Pharm, 411 (2011) 98-105

Scherließ, R. and Trows, S., Novel Formulation Concept for Particulate Uptake of Vaccines via the Nasal Associated Lymphoid Tissue, Procedia in Vaccinology, 4 (2011) 113-119

Scherließ, R. and Trows, S., Characterization of Nasal Deposition and Post-Nasal Fraction of a Model Vaccine Protein Formulation, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery Europe 2011 (2011) 321-325

Scherließ, R., In vitro particle deposition in the nasal cavity, Inhalation, 5 (2011) 14-18

Scherließ, R., Delivery of antigens used for vaccination - recent advances and challenges, Therapeutic Delivery 2 (2011) 1351-1368

2010


Westmeier, R., In vitro Screening Test for Respiratory Toxicity, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2010) 529-533

Westmeier, R., Novel Formulation Concept for Nasal Deposition of Dry Powder Vaccines, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2010) 523-527

2009


Westmeier, R. and Steckel, H., Zum Stellenwert der fixen Kombination von ß2-Sympathomimetika und Glucocorticoiden in der Asthmatherapie, PZ Prisma, 16 (2009) 13-24

2008


Westmeier, R. and Steckel, H., Combination particles of Salmeterol xinafoate and Fluticasone propionate: formulation and aerodynamic assessment, Journal of Pharmaceutical Sciences, 97 (2008) 2299-2310

2003


Heydenreich, A. V., Westmeier, R., Pedersen, N., Poulsen, H. S. and Kristensen, H. G., Preparation and purification of cationic solid lipid nanospheres - effects on particle size, physical stability and cell toxicity, Int J Pharm, 254 (2003) 83-87

 

Book chapter:
 
Zellnitz, S., Renner, N., Cui, Y., Scherließ, R., Sommerfeld, M., Steckel, H. and Urbanetz, N., 2019. The importance of interactions between carrier and drug particles for the application in dry powder inhalers, in: Antonyuk, S. (Ed.), Particles in Contact - Micro Mechanics, Micro Process Dynamics and Particle Collective. Springer Publishing Company

Scherließ, R., 2016. Particle Size Measurements in Aerosols, in: Müllertz, A., Perrie, Y., Rades, T. (Eds.), Analytical Techniques in the Pharmaceutical Sciences, CRS ed. Springer Nature, New York, pp. 701-715

Mönckedieck, M., Kamplade, J., Littringer, E.M., Mescher, A., Gopireddy, S., Hertel, M., Gutheil, E., Walzel, P., Urbanetz, N.A., Köster, M., Steckel, H. and Scherließ, R., 2016. Spray drying tailored mannitol carrier particles for dry powder inhalation with differently shaped active pharmaceutical ingredients, in: Fritsching, U. (Ed.), Process-Spray: Functional Particles Produced in Spray Processes. Springer International Publishing, pp. 517-566

Scherließ, R., 2015. Nasal delivery of vaccines, in: Foged, C., Rades, T., Perrie, Y., Hook, S. (Eds.), Delivery of subunit vaccines, CRS ed. Springer Science+Business Media, New York, pp. 287-306


Patents:

Hanefeld, A., Weigandt, M., Wolf, M., Knolle, P., Schröder, M., Scherließ, R., Walden, P., Diedrich, A., Steckel, H. and Baleeiro, R.B., Antigen-loaded chitosan nanoparticles for immunotherapy. Merck Patent Gesellschaft WO2015/185180A1

Scholz, M., Altrichter, J., Kemter, K., Scherließ, R. and Steckel, H., A novel method for the production of stabile vaccines, application number EP13190397.3 (2013)

 

PROF. DR. REGINA SCHERLIEß