ALL PUBLICATIONS

Peer-review Artikel (peer-review articles):


Scherließ, R., Future of nanomedicines for treating respiratory diseases. Expert Opinion Drug Delivery 16 (2019) 59-68

Hildebrandt, C., Gopireddy, S.R., Scherließ, R. and Urbanetz, N.A., Assessment of material and process attributes' influence on tablet quality using a QbD and DEM combined approach. Powder Technology 345 (2019) 390-404

Wöll, S., Bachran, C., Schiller, S., Schröder, M., Conrad, L., Scherließ, R. and Swee, L.K., Sortagging of liposomes with a murine-CD11b-specific VHH increases in vitro and in vivo targeting specificity of myeloid cells International Journal of Pharmaceutics  134 (2019) 190-198

Scherließ, R. and Etschmann, C., DPI formulations for high dose applications - challenges and opportunities. International Journal of Pharmaceutics 548 (2018) 49-53

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., Powder Flow Analysis: a Simple Method to Indicate the Ideal Amount of Lactose Fines in Dry Powder Inhaler Formulations. Int J Pharm 535 (2018) 59-67

Hildebrandt, C., Gopireddy, S., Scherließ, R. and Urbanetz, N.A., Numerical analysis of the die filling process within a pharmaceutical tableting machine. Chemie Ingenieur Technik 90 (2018) 483-492

Hildebrandt, C., Gopireddy, S.R., Scherließ, R., Urbanetz, N.A., 2018. Simulation of particle size segregation in a pharmaceutical tablet press lab-scale gravity feeder. Advanced Powder Technology 29, 765-780

Heidland, J., Helm, O., Lettau, M., Winter, E., Sebens, S. and Scherließ, R., Nano-in-microparticles for Dry Powder Vaccination – Nasal Application and Uptake in Immune Competent Cells, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 339-344

Jüptner, A., Hellfritzsch, M., Kaj, C., Vimont, A., Sarrailh, S., Grosjean, B., Williams, G. and Scherließ, R., Spray Dried Formulations for Nasal Applications – Challenges and Opportunities in Filling and Drug Delivery, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 345-348

Kobler, M., Hertel, M., Hauptstein, S., Scherließ, R. and Steckel, H., Influence of storage conditions on micronized lactose and the resulting ternary dry powder inhaler formulations, in: Dalby, R.e.a. (Ed.), Respiratory Drug Delivery. Davies Healthcare International Publishing, Tucson, AZ, USA (2018) 447-450

Rhein, N., Birk, G. and Scherließ, R., Influence of Drug Concentration on Dry Powder Inhaler Formulations Based on a Mannitol and a Lactose Carrier System, in: Dalby, R.et al. (Ed.), Respiratory Drug Delivery 2018. Davies Healthcare International Publishing, Tucson, USA (2018) 349-354

Tanabe, S., Nakagawa, H., Watanabe, T., Minami, H., Urbanetz, N.A. and Scherließ, R., Selection of a round convex tablet shape that mitigates the risk of chipping and capping based on systematic evaluation. European Journal of Pharmaceutical Sciences 120 (2018) 212-221

Wöll, S., Schiller, S., Bachran, C., Swee, L.K. and Scherließ, R., Pentaglycine lipid derivates – rp-HPLC-analytics for bioorthogonal anchor molecules in targeted, multiple-composite liposomal drug delivery systems. International Journal of Pharmaceutics  547 (2018) 602-610

Rhein, N., Birk, G. and Scherließ, R., Spray-granulated mannitol as a viable alternative for lactose in DPI formulations: Preparation of ordered mixtures and storage stability. Inhalation (2018) 17-23

Wöll, S., Conrad, L., Swee, L.K., Schiller, S., Bachran, C., Schröder, M. and Scherließ, R., Sortaggable liposomes: Evaluation of reaction conditions for single-domain antibody conjugation by Sortase A and targeting of CD11b+ myeloid cells. European Journal of Pharmaceutics and Biopharmaceutics 133 (2018) 138-150

Saarinen, J., Gütter, F., Lindman, M., Agopov, M., Fraser-Miller, S.J., Scherließ, R., Jokitalo, E., Santos, H.A., Peltonen, L., Isomäki, A. and Strachan, C., Cell-Nanoparticle Interactions at Sub(nanometer) Resolution Analysed by Electron Microscopy and Correlative Coherent Anti-Stokes Raman Scattering. Biotechnology Journal (2018) 1800413

Renner, N., Steckel, H., Urbanetz, N. and Scherließ, R., Nano- and Microstructured model carrier surfaces to alter dry powder inhaler performance. Int J Pharm 518 (2017) 20-28

Mönckedieck, M., Kamplade, J., Fakner, P., Urbanetz, N.A., Walzel, P., Steckel, H. and Scherließ, R., Dry powder inhaler performance of spray dried mannitol with tailored surface morphologies as carrier and salbutamol sulphate. Int J Pharm 524 (2017) 351-363

Armbruster, M., Mönckedieck, M., Scherließ, R., Daniels, R. and Wahl, M.A., Birch bark dry extract by supercritical fluid technology: extract characterisation and use for stabilisation of semisolid systems. ACS Applied Sciences 7 (2017)

Mönckedieck, M., Kamplade, J., Fakner, P., Urbanetz, N.A., Walzel, P., Steckel, H. and Scherließ, R., Spray drying of mannitol carrier particles with defined morphology and flow characteristics for dry powder inhalation. Drying Technology 35 (2017) http://dx.doi.org/10.1080/07373937.2017.1281291

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., An Easy Method to Indicate the Ideal Amount of Lactose Fines in Dry Powder Inhaler Formulations, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 189-193

Rhein, N., Birk, G. and Scherließ, R., Storage Stability of a Novel Mannitol Carrier in Dry Powder Inhalation Formulation, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 201-205

Renner, N., Steckel, H., Urbanetz, N. and Scherließ, R., Tailoring the Surface Topography of a Model Carrier to alter Dry Powder Inhaler Performance, in: Dalby, R. et al. (Ed.), Respiratory Drug Delivery Europe. Davies Healthcare International Publishing (2017) 195-199

Albrecht, S., Scherließ, R., Baehr, M., Goerke, A. and Langebrake, C., Umstellung häufig verordneter Kapselrezepturen in der Pädiatrie und Neonatologie auf flüssige Oralia im Krankenhaus. Krankenhauspharmazie 38 (2017) 459-468 (author prize 2018)

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., The Influence of High Shear Mixing on Ternary Dry Powder Inhaler Formulations. Int J Pharm 534 (2017) 242-250

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H., Scherließ, R., The influence of lactose fines in dry powder inhaler formulations. Inhalation 11 (2017) 22-26

Hildebrandt, C., Gopireddy, S.R., Fritsch, A.K., Profitlich, T., Scherließ, R. and Urbanetz, N.A., Evaluation and prediction of powder flowability in pharmaceutical tableting. Pharmaceutical Development and Technology 13 (2017) 1-13

Scherließ, R., Inhalativa – Arzneiformen zur lokalen und systemischen Gabe/ Inhaled dosage forms –formulations for local and systemic delivery, Pharmacon, 02/16 (2016)

Scherließ, R., Exploring the potential of mannitol as an alternative to lactose in dry powder inhalation, Inhalation (2016) 30-32

Trows, S. and Scherließ, R., Carrier-based dry powder formulation for nasal delivery of vaccines utilizing BSA as model drug Powder Technology 292 (2016) 223-231

Rietscher, R., Schröder, M., Janke, J., Czaplewska, J.A., Gottschaldt, M., Scherließ, R., Hanefeld, A., Schubert, U.S., Schneider, M., Knolle, P. and Lehr, C.-M., Antigen delivery via hydrophilic PEG-b-PAGE-b-PLGA nanoparticles boosts vaccination induced T cell immunity. EJPB 102 (2016) 20-31

Hertel, M., Littringer, E.M., Hauptstein, S., Dogru, M., Schwarz, E., Scherließ, R. and Steckel, H., The influence of high shear mixing parameters on the performance of ternary dry powder inhaler formulations, Respiratory Drug Delivery 2016, Phoenix, AZ, USA (2016)

Baleeiro, R.B., Schweinlin, M., Rietscher, R., Diedrich, A., Czaplewska, J.A., Metzger, M., Lehr, C.M., Scherließ, R., Hanefeld, A., Gottschaldt, M. and Walden, P., Nanoparticle-Based Mucosal Vaccines Targeting Tumor-Associated Antigens to Human Dendritic Cells. Journal of Biomedical Nanotechnology 12 (2016) 1-17

Hittinger, M., Janke, J., Huwer, H., Scherließ, R., Schneider-Daum, N. and Lehr, C.-M., Autologous co-culture of Primary Human Alveolar Macrophages and Epithelial Cells for Investigating Aerosol Medicines. Part I: Model Characterisation. Altern. Lab Anim. 44 (2016) 337-347

Dogru, M., Hertel, M., Littringer, E.M., Schwarz, E., Scherließ, R. and Steckel, H., Investigating the effect of mixing parameters and mixer type on the performance of ternary dry powder inhaler formulations, in: Dalby, R.et al. (Ed.), RDD Asia 2016. Davies Healthcare International Publishing, Goa, India (2016) 237-242

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S. and Hook, S., First in vivo evaluation of particulate nasal dry powder vaccine formulations containing ovalbumin in mice. Int J Pharm 479 (2015) 408-415

Scherließ, R., Diedrich, A., Ebensen, T., Guzmán, C.A., Wolf, M. and Hanefeld, A., Chitosan nanoparticulate formulation for pulmonary vaccination – formulation and in vivo proof of concept, RDD Europe. Dalby, R. et al., Antibes (2015)

Mönckedieck, M., Kamplade, J., Fakner, P., Scherließ, R., Walzel, P. and Steckel, H., The Impact of Particle Shape on the Dry Powder Inhaler Performance of Spray Dried Mannitol Carrier Particles, in: Dalby, R.N. (Ed.), RDD Europe, Antibes (2015)

Baleeiro, R.B., Rietscher, R., Diedrich, A., Czaplewska, J.A., Lehr, C.M., Scherließ, R., Hanefeld, A., Gottschaldt, M. and Walden, P., Spatial separation of the processing and MHC class I loading compartments for cross-presentation of the tumor-associated antigen HER2/neu by human dendritic cells. OncoImmunology 4 (2015) e1047585

Müller, T., Scherließ, R., Schiewe, J., Smal, R., Weiler, C. and Steckel, H., Applicability of a one-step DVS method for the determination of amorphous amounts for further different hydrophilic and hydrophobic drugs. European Journal of Pharmaceutics and Biopharmaceutics 94 (2015) 333-341

Ajmera, A. and Scherließ, R., Stabilisation of proteins via mixtures of amino acids during spray drying. Int J Pharm, 463 (2014) 98-107

Scherließ, R., Ajmera, A., Dennis, M., Carroll, M., Altrichter, J., Silman, N., Scholz, M., Kemter, K., Marriott, A., Induction of protective immunity against H1N1 influenza A with spray-dried and electron-beam sterilised vaccines in non-human primates. Vaccine 32 (2014) 2231-2240

Scherließ, R., Trows, S. and Buske, S., Overcoming challenges of inhaled vaccines through intelligent particle engineering, Inhalation, 6 (2013) 8-14

Scherließ, R., Mönckedieck, M., Young, K., Trows, S., Buske, S. and Hook, S., Evaluation of impact of nasal dry powder vaccine formulations on uptake and activation by dendritic cells. in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery Europe (2013) 279-283

Scherließ, R., Buske, S., Young, K., Weber, B., Rades, T. and Hook, S., In vivo evaluation of chitosan as an adjuvant in subcutaneous vaccine formulations. Vaccine 31 (2013) 4812-4819

Scherließ, R., Buske, S., Dry powder nanoparticulate formulations for mucosal vaccination, in Nanoformulation, edited by Tiddy G, Tan RB. Singapore, RSC Publishing (2012) 104-112

Trows, S. and Scherließ, R., Preparation and Characterization of Dry Powder Agarose Nano-in-Microparticles for Nasal Vaccination, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2012) 2, 491-496

Scherließ, R., Influences of Conditioning and Application Device on in vitro Nasal Deposition of a Dry Powder Vaccine Formulation, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2012) 2, 473-478

Zarie, E.S., Kaidas, V., Gedamu, D., Mishra, Y.K., Adelung, R., Furkert, F.H., Scherließ, R., Steckel, H. and Grössner-Schreiber, B., Solvent free fabrication of micro and nanostructured drug coatings by thermal evaporation for controlled release and increased effects, PLoS one (2012) 7(8), e40746

Scherließ, R., The MTT assay as tool to evaluate and compare excipient toxicity in vitro on respiratory epithelial cells, Int J Pharm, 411 (2011) 98-105

Scherließ, R. and Trows, S., Novel Formulation Concept for Particulate Uptake of Vaccines via the Nasal Associated Lymphoid Tissue, Procedia in Vaccinology, 4 (2011) 113-119

Scherließ, R. and Trows, S., Characterization of Nasal Deposition and Post-Nasal Fraction of a Model Vaccine Protein Formulation, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery Europe 2011 (2011) 321-325

Scherließ, R., In vitro particle deposition in the nasal cavity, Inhalation, 5 (2011) 14-18

Scherließ, R., Delivery of antigens used for vaccination - recent advances and challenges, Therapeutic Delivery 2 (2011) 1351-1368

Westmeier, R., In vitro Screening Test for Respiratory Toxicity, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2010) 529-533

Westmeier, R., Novel Formulation Concept for Nasal Deposition of Dry Powder Vaccines, in Dalby, R.N. et al. (Ed.) Respiratory Drug Delivery (2010) 523-527

Westmeier, R. and Steckel, H., Zum Stellenwert der fixen Kombination von ß2-Sympathomimetika und Glucocorticoiden in der Asthmatherapie, PZ Prisma, 16 (2009) 13-24

Westmeier, R. and Steckel, H., Combination particles of Salmeterol xinafoate and Fluticasone propionate: formulation and aerodynamic assessment, Journal of Pharmaceutical Sciences, 97 (2008) 2299-2310

Heydenreich, A. V., Westmeier, R., Pedersen, N., Poulsen, H. S. and Kristensen, H. G., Preparation and purification of cationic solid lipid nanospheres - effects on particle size, physical stability and cell toxicity, Int J Pharm, 254 (2003) 83-87

Monographie (monograph):


Westmeier, R., Inhalative Kombinationspräparate durch Co-Präzipitation, Dissertation, Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University, Kiel (2008)

Buchkapitel (book chapter):


Scherließ, R., 2016. Particle Size Measurements in Aerosols, in: Müllertz, A., Perrie, Y., Rades, T. (Eds.), Analytical Techniques in the Pharmaceutical Sciences, CRS ed. Springer Nature, New York, pp. 701-715

Mönckedieck, M., Kamplade, J., Littringer, E.M., Mescher, A., Gopireddy, S., Hertel, M., Gutheil, E., Walzel, P., Urbanetz, N.A., Köster, M., Steckel, H. and Scherließ, R., 2016. Spray drying tailored mannitol carrier particles for dry powder inhalation with differently shaped active pharmaceutical ingredients, in: Fritsching, U. (Ed.), Process-Spray: Functional Particles Produced in Spray Processes. Springer International Publishing, pp. 517-566

Scherließ, R., 2015. Nasal delivery of vaccines, in: Foged, C., Rades, T., Perrie, Y., Hook, S. (Eds.), Delivery of subunit vaccines, CRS ed. Springer Science+Business Media, New York, pp. 287-306

Patentanmeldungen/erteilte Patente (patents):


Hanefeld, A., Weigandt, M., Wolf, M., Knolle, P., Schröder, M., Scherließ, R., Walden, P., Diedrich, A., Steckel, H. and Baleeiro, R.B., Antigen-loaded chitosan nanoparticles for immunotherapy. Merck Patent Gesellschaft WO2015/185180A1

Scholz, M., Altrichter, J., Kemter, K., Scherließ, R. and Steckel, H., A novel method for the production of stabile vaccines, application number EP13190397.3 (2013)

Konferenzbeiträge (conference contributions):


Bock, S. and Scherließ, R., Particle engineering for Dry Powder Inhalation (DPI): Modifying drug-to-carrier interaction in adhesive mixtures, 1st annual Nordic POP meeting, Oslo, Norway (2019), oral presentation

Gutowski, T. and Scherließ, R., Cannabidiol in a DPI – maximising the spray drying yield of HPMC matrix particles Drug Delivery to the Lungs 2018, Edinburgh, UK (2018)

Etschmann, C. and Scherließ, R., Softpellets for high dose pulmonary delivery, Drug Delivery to the Lungs 2018, Edinburgh, UK (2018)

Rhein, N., Birk, G. and Scherließ, R., A closer look on the dispersion behaviour of Parteck® M DPI – based interactive mixtures: improving the fine particle fraction by the addition of fines, Drug Delivery to the Lungs 2018, Edinburgh, Scotland (2018)

Jüptner, A., Sarrailh, S. and Scherließ, R., Spray dried powders for nasal application - Influence of particle morphology and filling process on aerosol generation, Drug Delivery to the Lungs 2018, Edinburgh, Scotland (2018)

Hellfritzsch, M. and Scherließ, R., Characterisation of Zinc Oxide as an Alternative to Aluminum Hydroxide in Nasal Vaccination, Drug Delivery to the Lungs 2018, Edinburgh, Scotland (2018)

Scherließ, R., Reinauer, E. and Kemter, K., Stability of Dry Powder Vaccines, 12th Vaccine Congress, Budapest, Hungary (2018)

Tanabe, S., Gopireddy, S., Ando, S., Minami, H., Urbanetz, N.A. and Scherließ, R., Prediction of Blend Uniformity by utilizing Discrete Element Method simulation, AIChE Annual Meeting, Pittsburgh, USA (2018) selected for oral presentation

Hildebrandt, C., Gopireddy, S.R., Scherließ, R. and Urbanetz, N., Impact of force feeder geometry on powder flow, 11th World Meeting of Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain (2018)

Jüptner, A., Hellfritzsch, M., Kaj, C., Vimont, A., Sarrailh, S., Williams, G. and Scherließ, R., Spray dried formulations for inhalation - influence of particle shape, 11th World Meeting of Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain (2018)

Rhein, N., Birk, G. and Scherließ, R., Influence of carrier particle size distribution and inhaler devices on aerodynamic performance, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain (2018)

Heidland, J. and Scherließ, R., Aerodynamic characterisation of nano-in-microparticulate formulation for dry powder vaccination, 11th World Meeting of Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain (2018) 396-399

Tanabe, S., Gopireddy, S., Ohno, I., Minami, H., Ando, S., Scherließ, R. and Urbanetz, N.A., Blend Uniformity Prediction based on Discrete Element Method (DEM) Simulation, World Meeting of Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain (2018)

Hellfritzsch, M. and Scherließ, R., Characterisation of Zinc Oxide Particles as Protein Carrier System, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain (2018)

Gutowski, T. and Scherließ, R., Cannabidiol in a DPI – Preliminary experiments to screen formulation technologies and excipients, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Granada, Spain (2018)

Saarinen, J., Gütter, F., Lindman, M., Fraser-Miller, S., Scherließ, R., Isomäki, A., Jokitalo, E., Santos, H.A., Peltonen, L. and Strachan, C., Synergistic Analysis of Nanoparticle Cellular Uptake Using Correlative Coherent Anti-Stokes Raman Scattering and Electron Microscopy, Finnish Physical Pharmacy Society meeting (2018)

Gütter, F., Saarinen, J., Peltonen, L., Santos, H., Strachan, C. and Scherließ, R., Understanding nano-bio interactions by characterisation of nanocrystal-cell relations, 22nd annual meeting CRS Germany local chapter, Halle (2018)

Winter, E., Lettau, M., Heidland, J., Scherließ, R., Walter, F., Helm, O. and Sebens, S., Tumor vaccination: chitosan nanoparticles to improve the antigen uptake by dendritic cells for an enhanced tumor-directed immune response, 5th European Congress of Immunology, Amsterdam, The Netherlands (2018)

Wöll, S., Gockel, L.M., Schiller, S. and Scherließ, R., Spray drying of Liposomes: Surface Stabilizer Relationship, CRS local chapter Germany annual meeting, Marburg (2017), oral presentation

Heidland, J. and Scherließ, R., Nano-in-microparticles for dry powder vaccination via the respiratory tract, CRS local chapter Germany annual meeting, Marburg (2017)

Rhein, N., Birk, G. and Scherließ, R., Parteck M DPI – a novel mannitol as carrier in dry powder inhalation formulations, 2nd European Conference on Pharmaceutics, Krakow, Poland (2017) 139-142

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., How to determine the ideal amount of fines in dry powder inhaler formulations?, 9th Polish-German Symposium on Pharmaceutical Sciences, Krakow, Poland (2017)

Gütter, F., Peltonen, L., Strachan, C. and Scherließ, R., Nanocrystal production: Understanding stabiliser-drug interaction, 9th Polish-German Symposium on Pharmaceutical Sciences, Krakow, Poland (2017)

Rhein, N., Birk, G. and Scherließ, R., Storage stability of a novel mannitol carrier in a dry powder inhalation formulation 9th Polish-German Symposium on Pharmaceutical Sciences, Krakow, Poland (2017)

Saarinen, J., Gütter, F., Fraser, S., Isomäki, A., Antikainen, O., Scherließ, R., Jokitalo, E., Santos, H., Peltonen, L. and Strachan, C., Correlative light-electron microscopy (CLEM) of drug nano-/microcrystal cellular uptake with coherent anti-Stokes Raman scattering (CARS) CRS Nordic Chapter Meeting, Kuopio, Finland (2017)

Hildebrandt, C., Gopireddy, S., Scherließ, R. and Urbanetz, N.A., Numerical analysis of the die filling process within a pharmaceutical tableting machine, 8. Symposium Produktgestaltung in der Partikeltechnologie. Fraunhofer ICT, Karlsruhe (2017) oral presentation

Hildebrandt, C., Gopireddy, S., Scherließ, R. and Urbanetz, N.A., Powder flow within a pharmaceutical tablet press – a DEM analysis, V International Conference on Particle-Based Methods - Fundamentals and Applications PARTICLES2017, Hanover (2017) oral presentation

Hildebrandt, C., Gopireddy, S.R., Profitlich, T., Scherließ, R. and Urbanetz, N.A., Assessment of powder flowability in pharmaceutical tableting 10th World Congress of Chemical Engineering, Barcelona, Spain (2017) oral presentation

Renner, N., Steckel, H., Urbanetz, N.A., Scherließ, R., 2017. What could be learned from glass beads as model carrier system?, Drug Delivery to the Lungs 2017, Edinburgh, UK, pp. 250-253

Rhein, N., Birk, G., Girreser, U. and Scherließ, R., Stability of Formoterol as model for a reduction sensitive material in blends for inhalation, Drug Delivery to the Lungs 2017, Edinburgh, UK (2017)

Scherließ, R., Jüptner, A., Hellfritzsch, M., Kaj, C., Sarrailh, S., Vimont, A. and Williams, G., Spray dried formulations for pulmonary delivery – challenges in filling, aerosol generation and delivery, Drug Delivery to the Lungs 2017, Edinburgh, UK (2017)

Heidland, J. and Scherließ, R., Nano-in-microparticles for dry powder vaccination – possible for nasal application? , Drug Delivery to the Lungs 2017, Edinburgh, UK (2017) 396-399 (best academic poster)

Hertel, M., Schwarz, E., Kobler, M., Hauptstein, S., Steckel, H. and Scherließ, R., Influence of storage conditions on ternary dry powder inhaler formulations, Drug Delivery to the Lungs 2017, Edinburgh, UK (2017)

Saarinen, J., Gütter, F., Fraser, S., Isomäki, A., Antikainen, O., Scherließ, R., Peltonen, L., Santos, H.A. and Strachan, C.J., Visualisation of nanocrystal-cell interactions using coherent-anti Stokes Raman scattering (CARS) microscopy combined to multivariate data-analysis, Northern Pharma Network Meeting Helsinki, Finland (2016)

Saarinen, J., Gütter, F., Fraser, S., Isomäki, A., Antikainen, O., Scherließ, R., Peltonen, L., Santos, H.A. and Strachan, C.J., Multiplex coherent anti-Stokes Raman scattering (CARS) microscopy with multivariate data-analysis as a visualisation tool for probing un-labeled drug nanocrystals in cells, 27th Annual Symposium of the Finnish Society of Physical Pharmacy Helsinki, Finland (2016)

Saarinen, J., Gütter, F., Fraser, S., Isomäki, A., Antikainen, O., Scherließ, R., Peltonen, L., Santos, H.A. and Strachan, C.J., Visualisation of un-labeled drug nanocrystals in cells using coherent anti-Stokes Raman scattering (CARS) microscopy combined to multivariate data-analysis, Bridging Nordic Imaging and Cellular Imaging workshop, Gothenburg, Sweden (2016)

Heidland, J. and Scherließ, R., NiM powders for nasal vaccination – insights into particle forming process, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Renner, N., Scherließ, R. and Steckel, H., Investigating the influence of carrier surface roughness on drug delivery by DPIs, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Hertel, M., Scherließ, R., Schwarz, E., Littringer, E.M., Dogru, M., Hauptstein, S. and Steckel, H., Influence of fines on commercial lactose carriers and their dry powder inhalation performance, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Hildebrandt, C., Scherließ, R., Gopireddy, S. and Urbanetz, N.A., Numerical analysis of die filling process within a lab scale pharmaceutical tableting machine, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Arntz, P., Nassut, R., Steckel, H. and Scherließ, R., Pressurised bone void filler formulation, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Rhein, N., Birk, G. and Scherließ, R., Influence of different inhalers on fine particle fraction of mannitol carriers in dry powder inhaler formulations, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Mönckedieck, M., Scherließ, R., Kamplade, J., Walzel, P., Urbanetz, N.A. and Steckel, H., Spray dried mannitol carriers in inhalation – the influence of surface energy and API distribution on drug detachment, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Saarinen, J., Gütter, F., Fraser, S., Isomäki, A., Antikainen, O., Scherließ, R., Peltonen, L., Santos, H.A. and Strachan, C.J., Multiplex coherent anti-Stokes Raman scattering (CARS) microscopy as a visualisation technique to probe drug nanocrystal–cell interactions, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Gütter, F., Scherließ, R., Steckel, H., Saarinen, J., Strachan, C.J., Santos, H.A. and Peltonen, L., Production of nanocrystals and uptake studies in Caco-2 cells World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology Glasgow, UK (2016)

Wöll, S., Schiller, S. and Scherließ, R., Directional liposome functionalization using enzyme – mediated single-domain antibody conjugation, World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK (2016)

Renner, N., Scherließ, R. and Steckel, H., Glass beads as model carriers in dry powder inhalers:  Investigating the influence of surface coverage on inhalation performance, PARTEC, Nueremberg (2016)

Hildebrandt, C., Gopireddy, S.R., Scherließ, R. and Urbanetz, N.A., Simulation of powder flow within the force feeder of a pharmaceutical tablet press, PARTEC, Nueremberg (2016)

Albold, D. and Scherließ, R., Suitability of Microemulsions as Vehicle System for Dermal Protein Application, DPhG annual meeting, Munich, Germany (2016)

Hildebrandt, C., Gopireddy, S., Scherließ, R. and Urbanetz, N.A., Numerical analysis of powder flow in a lab-scale tableting machine, DPhG annual meeting, Munich, Germany (2016)

Wöll, S., Schiller, S. and Scherließ, R., Sortase-A mediates VHH – conjugation to differently PEGylated liposomes, DPhG annual meeting, Munich (2016)

Mönckedieck, M., Kamplade, J., Walzel, P., Steckel, H., Urbanetz, N.A. and Scherließ, R., Detachment of various spray dried drug particles from engineered mannitol carriers, Drug Delivery to the Lungs 27, Edinburgh, UK (2016) 146-149

Heidland, J. and Scherließ, R., Nano- in Microparticle powders for mucosal vaccination – understanding the particle forming process, Drug Delivery to the Lungs 27, Edinburgh, UK (2016) 110-113

Rhein, N., Birk, G. and Scherließ, R., Parteck M DPI – a novel mannitol as carrier in dry powder inhalation formulations, Drug Delivery to the Lungs 27, Edinburgh, UK (2016) 139-142

Renner, N., Steckel, H., Urbanetz, N.A. and Scherließ, R., A deeper insight into the impact of chemical surface properties on inhalation performance, Drug Delivery to the Lungs 27, Edinburgh, UK (2016) 316-319

Hertel, M., Schwarz, E., Littringer, E.M., Dogru, M., Hauptstein, S., Scherließ, R. and Steckel, H., The influence of the blender on the performance of ternary dry powder inhaler formulations, Drug Delivery to the Lungs 27, Edinburgh, UK (2016) 57-60

Albold, D., Scherließ, R., Proksch, E. and Steckel, H.A., Evaluation of Microneedle Devices for the Application of Dermal Protein Formulations, 4th Galenus Workshop "Drug Delivery to Human Skin", Saarbrücken (2015)

Hittinger, M., Mell, N., Janke, J., Huwer, H., Scherließ, R., Loretz, B., Schneider-Daum, N. and Lehr, C.-M., Autologous coculture of human alveolar cells for safety testing of airborne particles, Nano meets Future, Saarbrücken (2015)

Renner, N., Scherließ, R. and Steckel, H., Tailoring spray dried API particles of salbutamol sulphate and ipratropium bromide, 8th Polish German Symposium on Pharmaceutical Sciences, Kiel (2015)

Albold, D., Scherließ, R., Proksch, E. and Steckel, H., Evaluation of Microneedle Devices for the Application of Dermal Protein Formulations, 8th Polish German Symposium on Pharmaceutical Sciences, Kiel (2015)

Gütter, F., Scherließ, R. and Steckel, H., Stabilisers in nanocrystal production: Concentration dependency and cell toxicity, 8th Polish German Symposium on Pharmaceutical Sciences, Kiel (2015)

Heidland, J. and Scherließ, R., DC2.4 as an in-vitro test system for characterisation of promising formulations for nasal vaccination, 8th Polish German Symposium on Pharmaceutical Sciences, Kiel (2015)

Arntz, P., Scherließ, R. and Steckel, H., Optimisation of Calcium Phosphate Delivery from HFA-Suspensions, 8th Polish German Symposium on Pharmaceutical Sciences, Kiel, Germany (2015)

Mönckedieck, M., Kamplade, J., Fakner, P., Scherließ, R., Steckel, H. and Walzel, P., Impact of size and surface morphology of mannitol carrier particles on the FPF of DPI formulations, ISAM, Munich, Germany (2015)

Arntz, P., Nassut, R., Scherließ, R. and Steckel, H., Novel foamable cement formulation for application of antibiotics to bone voids, DPhG annual meeting, Düsseldorf, Germany (2015)

Hildebrandt, C., Gopireddy, S.R., Scherließ, R. and Urbanetz, N.A., Application of numerical simulations in pharmaceutical tableting, DPhG annual meeting, Düsseldorf (2015)

Albold, D. and Scherließ, R., Phospholipid-based microemulsions for the dermal application of proteins, 4th Symposium on Phospholipids in Pharmaceutical Research, Heidelberg, Germany (2015)

Wöll, S., Schiller, S. and Scherließ, R., Spray Drying of antigen – loaded DOTAP liposomes as powdered pulmonary vaccine, Symposium on Phospholipids in Pharmaceutical Research, Heidelberg, Germany (2015)

Saarinen, J., Gütter, F., Darville, N., Isomäki, A., Scherließ, R., Van den Mooter, G., Peltonen, L., Santos, H.A. and Strachan, C.J., Visualisation of itraconazole and glibenclamide nanocrystal cell uptake using coherent anti-Stokes Raman scattering (CARS) microscopy, FIP, Düsseldorf, Germany (2015)

Hertel, M., Schwarz, E., Littringer, E.M., Dogru, M., Scherließ, R. and Steckel, H., Influence of fines on commercial lactose carriers and their dry powder inhalation performance, Drug Delivery to the Lungs 26, Edinburgh, UK (2015)

Renner, N., Todorova, Z., Scherließ, R. and Steckel, H., Modified glass beads as model carriers to understand the performance of interactive powder blends, Drug Delivery to the Lungs 26, Edinburgh, UK (2015)

Mönckedieck, M., Kamplade, J., Walzel, P., Steckel, H. and Scherließ, R., Influence of mannitol carrier morphology on the DPI performance of different APIs, Drug Delivery to the Lungs 26, Edinburgh, UK (2015)

Rhein, N., Birk, G. and Scherließ, R., Characterisation of particle engineered Mannitol as alternative carriers in dry powder inhalation formulations, Drug Delivery to the Lungs 26, Edinburgh, UK (2015)

Mönckedieck, M., Scherließ, R., Steckel, H., 2014. Tailored salbutamol sulphate particles for dry powder inhalation by adjusting spray drying parameters, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon

Diedrich, A. and Scherließ, R., Chitosan Nanoparticles for Pulmonary Protein Delivery, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon (2014)

Janke, J. and Scherließ, R., Vaccination via the respiratory tract - porous PLGA-nanoparticles for a faster release, 9th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Lisbon (2014)

Baleeiro, R.B., Rietscher, R., Diedrich, A., Scherließ, R., Hanefeld, A. and Walden, P., Cross-presentation of the tumor antigen Her2/neu involves neither the canonical nor the endosomal pathway – A novel MHC class I cross-presentation compartment in DCs, DC2014, Tours, France (2014)

Hanefeld, A., Schiller, S., Wolf, A., Weigandt, M., Scherließ, R., Diedrich, A., Janke, J., Knolle, P., Schröder, M., Walden, P., Baleerio, R., Lehr, C.M., Rietscher, R. and Schneider, M., Dendritic cell-targeting cancer vaccine formulations for pulmonary and peroral delivery, DPhG annual meeting, Frankfurt (2014)

Diedrich, A. and Scherließ, R., Stability of a Respirable Dry Powder Vaccine, DDL 25, Edinburgh, Scotland (2014)

Scherließ, R., Dennis, M., Carroll, M., Altrichter, J., Ajmera, A., Silman, N. et al., Protective immunization against H1N1 influenza A with spray-dried and electron-beam sterilized vaccines in non-human primates, 7th Vaccine and ISV Congress, Barcelona, Spain (2013) oral presentation

Janke, J. and Scherließ, R., Aerodynamic characterisation of PLGA nanoparticulate dry powder formulation for vaccine delivery via the respiratory tract, Proceedings of DDL 24, Edinburgh, Scotland (2013)

Buske, S. and Scherließ, R., Nasal deposition analysis of a nano-in-microparticle vaccine formulation in children and adults using cast models, Proceedings of DDL 24, Edinburgh, Scotland (2013)

Ajmera, A. and Scherließ, R., Dry Powder Formulation of Proteins via Spray Drying, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey (2012)

Buske, S. and Scherließ, R., Dispersion Behaviour of Dry Powder Nanoparticle-in-Microparticle Formulations for Nasal Vaccine Delivery, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey (2012)

Trows, S. and Scherließ, R., Stability of Antigen Loaded Dry Powder Microparticles for Nasal Vaccination, 8th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Istanbul, Turkey (2012)

Buske, S. and Scherließ, R., First steps in the development of a dry powder formulation for pulmonary vaccine delivery. Proceedings of DDL 23, Edinburgh, Scotland (2012) 353-356

Trows, S. and Scherließ, R., Release from antigen-loaded agarose nano-in-microparticles for nasal vaccination. Proceedings of DDL 23, Edinburgh, Scotland (2012) 333-336

Janke, J. and Scherließ, R., PLGA nanoparticles for vaccine delivery to the respiratory tract. Proceedings of DDL 23, Edinburgh, Scotland (2012) 357-360

Trows, S. and Scherließ, R., Development of a dry powder nasal vaccine formulation, 6th Polish-German Symposium, Düsseldorf, Germany (2011)

Buske, S. and Scherließ, R., Dry Powder Nanoparticulate Formulations for Mucosal Vaccination, ICMAT: NanoFormulation, Singapore (2011)

Scherließ, R., In vitro evaluation of dry powder nasal deposition from a single use nasal device, proceedings of DDL 22, Edinburgh, Scotland (2011) 189-192

Trows, S. and Westmeier, R., Development of a dry powder formulation for nasal vaccination, 7th World Congress of Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Valetta, Malta (2010)

Trows, S. and Scherließ, R., Development of a dry powder formulation for nasal vaccination, DPhG annual meeting, Braunschweig, Germany (2010)

Scherließ, R. and Trows, S., Novel Formulation Concept for Particulate Uptake of Vaccines via the Nasal Associated Lymphoid Tissue, Vaccine and ISV Annual Global Congress, Vienna, Austria (2010)

Scherließ, R., Comparison of in vitro methods to determine nasal versus lung deposition of a protein formulation, DDL 21, Edinburgh, Scotland (2010) 311-314, poster and oral presentation (Pat Burnell Award)

Westmeier, R., Rapid in-vitro screening test for respiratory toxicity, DDL20, Edinburgh, Scotland (2009) 20-23, oral presentation

Westmeier, R., Dubois, J., Lewis, N. and Steckel, H., Qualitative analysis of combination particles for pulmonal delivery, 6th World Meeting of Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology Barcelona, Spain (2008)

Westmeier, R. and Steckel, H., In-situ fine particle excipient as dispersion modifier for a dry powder inhalation product, proceedings of DDL 19, Edinburgh, Scotland (2008) 132-134

Westmeier, R. and Steckel, H., Aerodynamic assessment of salmeterol xinafoate and fluticasone propionate co-precipitates, proceedings of DDL 18, Edinburgh, Scotland (2007) 116-119

Westmeier, R. and Steckel, H., Enhanced dissolution of a new dry powder inhaler formulation, DPhG Joint Meeting, Erlangen, Germany (2007)

Westmeier, R. and Steckel, H., Dual particles containing Salmeterol xinafoate and Fluticasone propionate, proceedings of DDL 17, Edinburgh, Scotland (2006) 279-282

Vorträge auf Einladung (invited talks):


Scherließ, R., Inhaled drug delivery – formulation technologies for dry powder inhalation, 11th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. APV, Granada, Spain (2018), plenary lecture

Scherließ, R., Formulation, deposition and effect of nasal medications, Nasal Drug Delivery: annual conference. Management Forum, London, UK (2018)

Scherließ, R., Mucosal vaccination via the respiratory tract, 5th Pulmonary Drug Delivery Workshop, Dublin, Ireland (2018)

Scherließ, R., Drug Delivery Formulations for the Respiratory Tract, Seminar, Leibniz Research Center Borstel, Germany (2017)

Scherließ, R., Drug delivery by inhalation – formulation and characterization, Guest lecture. School of Pharmacy, UiO, Oslo, Norway (2017)

Scherließ, R., Nanoparticles for immune actives, Guest lecture. School of Pharmacy, UiO, Oslo, Norway (2017)

Seidel, K. and Scherließ, R., Kapseln - Herstellungstechniken, Herstellungsprobleme, Anwendung, Rezepturbeispiele, Spezialfälle. DAZ, Interpharm 2017 Bonn (2017)

Scherließ, R., Formulation, deposition and effect of nasal medications, Nasal Drug Delivery: annual conference. Management Forum, London, UK (2017)

Scherließ, R., Parameters influencing the performance of interactive blends for inhalation, Dry Powder Inhalers: annual conference. Management Forum, London, UK (2017)

Scherließ, R., Mucosal vaccination via the respiratory tract, 4th Pulmonary Drug Delivery Workshop, Istanbul, Turkey (2017)

Scherließ, R., Nanoparticulate systems for respiratory delivery, Drug Delivery to the Lungs 2017, Edinburgh, Scotland (2017)

Scherließ, R., Drug Delivery Systems for Respiratory Vaccination, Sackler Seminar, King's College, London, UK (2016)

Scherließ, R., Particulate systems in nasal delivery, Woolcock Institute of Medical Research Seminar, Sydney, Australia (2016)

Scherließ, R., Solution, Suspension or Engineered Particles? Advantages of Particulate Drug Delivery to the Nose, Nasal Drug Delivery Conference. Management Forum, London, UK (2016)

Scherließ, R., Innovative Darreichungsformen, DPhG Landesgruppe Schleswig-Holstein, Kiel, Germany (2016)

Scherließ, R., Mannitol as an Alternative to Lactose in Dry Powder Inhalation, Dry Powder Inhalers: annual conference. Management Forum, London, UK (2016)

Scherließ, R., Vaccine delivery via the lungs, Inhaled Drug Delivery: annual conference. Management Forum, London, UK (2016)

Scherließ, R., Inhaled Drug Delivery – just Asthma and COPD?, Inhaled Drug Delivery: annual conference. Management Forum, London, UK (2016)

Scherließ, R., Disperse Systems in Dosage Forms, Helsinki University, Finland (2015)

Scherließ, R., Particulate systems for nasal (vaccine) delivery. Nasal Drug Delivery Conference, Management Forum, London, UK (2015)

Scherließ, R., Rezeptur – Fehler erkennen und vermeiden, 8. Niedersächsischer Apothekertag, Stade, Germany (2015)

Scherließ, R., (Lipid) particle engineering for pulmonary delivery, 4th Symposium on Phospholipids in Pharmaceutical Research, Heidelberg, Germany (2015)

Scherließ, R., Particulate systems for nasal (vaccine) delivery. Nasal Drug Delivery Conference, Management Forum, London, UK (2014)

Scherließ, R., Dry Powder Formulations for Nasal Vaccines, CRS Germany Local Chapter meeting, Ludwigshafen, Germany (2013)

Scherließ, R., Nasal Vaccine Therapy and Delivery: Recent Developments, Nasal and Buccal Drug Delivery Conference, Management Forum, London, UK (2013)

Scherließ R., Applicable Therapies and Current Thinking on Intranasal Vaccine Delivery.  pre-conference workshop "Nasal Drug Delivery Masterclass" to Inhalation Drug Delivery. Berlin, Germany, CPhI, (2013)

Scherließ R., Vaccine delivery via the lungs, 2nd Galenus workshop: Pulmonary Drug Delivery, Dublin, Ireland (2013)

Scherließ, R., Nasal delivery of vaccines: formulation and device, 14th Annual Conference Formulation and Delivery of Bioactives, Dunedin, New Zealand (2012)

Scherließ, R., Dry Powder Formulations for Nasal Vaccination, Nasal and Buccal Drug Delivery Conference, Management Forum, London, UK (2012)

Scherließ, R., Overcoming the challenges of inhalable vaccines through clever particle engineering, 4th Annual Inhalation Drug Development, informa, Munich, Germany (2012)

Scherließ, R., Neue Apothekenbetriebsordnung – Plausibilitätsprüfung, BVDD Mitgliederversammlung Schleswig-Holstein, Kiel, Germany (2012)

Scherließ, R., Mucosal Vaccination via the Respiratory Tract, 6th Polish-German Symposium, Düsseldorf, Germany (2011)