Publikationen

 

2020

Bader, A., Beitz, E. (2020) Transmembrane facilitation of lactate/H+ instead of lactic acid is not a question of semantics but of cell viability. Membranes 10: E236. PubMed

Walloch, P., Henke, B., Häuer, S., Bergmann, B., Spielmann, T., Beitz, E., (2020) Introduction of scaffold nitrogen atoms renders inhibitors of the malarial L-lactate transporter, PfFNT, effective against the Gly107Ser resistance mutation. J. Med. Chem. [EPub ahead of print] PubMed

Kreiter, J., Beitz, E., Pohl, E.E. (2020) A fluorescence-based method to measure ADP/ATP exchange of recombinant adenine nucleotide translocase in liposomes. Biomolecules 10: E685. PubMed

 

2019

Hajek, P., Bader, A., Helmstetter, F., Henke, B., Arnold, P., Beitz, E. (2019) Cell-free and yeast-based production of the malarial lactate transporter, PfFNT, delivers comparable yield and protein quality. Front. Pharmacol. 10: 375. PubMed

Helmstetter, F., Arnold, P., Höger, B., Petersen, L.M., Beitz, E. (2019) Formate-nitrite transporters carrying nonprotonatable amide amino acids instead of a central histidine maintain pH-dependent transport. J. Biol. Chem. 294: 623-631. PubMed

 

2018

Erler, H., Ren, B., Gupta, N., Beitz, E. (2018) The intracellular parasite Toxoplasma gondii harbors three druggable FNT-type formate and L-lactate transporters in the plasma membrane. J. Biol. Chem. 293: 17622-17630. PubMed

Uzcategui, N.L., Figarella, K., Segninia, A., Marsiccobetrea, S., Lang, F., Beitz, E., Rodriguez-Acosta, A., Bertl, A. (2018) Trypanosoma brucei aquaglyceroporins mediate the transport of metabolic end-products: methylglyoxal, D-lactate, L-lactate and acetate. Biochim. Biophys. Acta Biomembr. 1860: 2252-2261. PubMed

Meier, A., Erler, H., Beitz, E. (2018) Targeting channels and transporters in protozoan parasite infections. Front. Chem. 6: 88. PubMed

 

2017

Wiechert, M., Erler, H., Golldack, A., Beitz, E. (2017) A widened substrate selectivity filter of eukaryotic formate-nitrite transporters enables high-level lactate conductance. FEBS J. 284: 2663-2673. PubMed

Wiechert, M., Beitz, E. (2017) Formate-nitrite transporters: monoacids ride the dielectric slide. Channels 11: 365-367. PubMed

Rothert, M., Rönfeldt, D., Beitz, E. (2017) Electrostatic attraction of weak monoacid anions increases probability for protonation and passage through aquaporins. J. Biol. Chem. 292: 9358-9364. PubMed

Scheltz, T., von Bülow, J., Beitz, E. (2017) Reducing isoform complexity of human tetraspanins by optimized expression in Dictyostelium discoideum enables high-throughput functional read-out. Protein Expr. Purif. 135: 8-15. PubMed

Wiechert, M., Beitz, E. (2017) Mechanism of formate-nitrite transporters by dielectric shift of substrate acidity. EMBO J. 36: 949-958. PubMed

Golldack, A., Henke, B., Bergmann, B., Wiechert, M., Erler, H., Blancke Soares, A., Spielmann, T., Beitz, E. (2017) Substrate-analogous inhibitors exert antimalarial action by targeting the Plasmodium lactate transporter PfFNT at nanomolar scale. PLoS Pathog. 13: e1006172. PubMed

 

2016

Albers, T., Maniak, M., Beitz, E., von Bülow, J. (2016) The C isoform of Dictyostelium tetraspanins localizes to the contractile vacuole and contributes to resistance against osmotic stress. PLoS One11: e0162065. PubMed

Holm-Bertelsen, J., Bock, S., Helmstetter, F., Beitz, E. (2016) High-level cell-free production of the malarial lactate transporter PfFNT as a basis for crystallization trials and directional transport studies. Protein Expr. Purif. 126: 109-114. PubMed   /   Layman summary at Atlas of Science

von Bülow, J., Beitz, E. (2016) Attacking aquaporin water and solute channels of human-pathogenic parasites: new routes for treatment? in Aquaporins in Health and Disease CRC Press

Song, J., Baker, N., Rothert, M., Henke, B., Jeacock, L., Horn, D., Beitz, E. (2016) Pentamidine is not a permeant but a nanomolar inhibitor of the Trypanosoma brucei aquaglyceroporin-2. PLoS Pathog. 12: e1005436. PubMed

 

2015

Beitz, E., Golldack, A., Rothert, M., von Bülow, J. (2015) Challenges and achievements in the therapeutic modulation of aquaporin functionality. Pharmacol. Ther. 155: 22-35. PubMed

von Bülow, J., Beitz, E. (2015) Number and regulation of protozoan aquaporins reflect environmental complexity. Biol. Bull. 229: 38-46. PubMed

Wu, B., Rambow, J., Bock, S., Holm-Bertelsen, J., Wiechert, M., Blancke Soares, A., Spielmann, T., Beitz, E. (2015) Identity of a Plasmodium lactate/H+ symporter structurally unrelated to human transporters. Nat. Commun. 6: 6284. PubMed

von Bülow, J., Golldack, A., Albers, T., Beitz, E. (2015) The amoeboidal Dictyostelium aquaporin AqpB is gated via Tyr216 and aqpB gene deletion affects random cell motility. Biol. Cell 107: 78-88. PubMed

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Geadkaew, A., von Bülow, J., Beitz, E., Tesana, S., Grams, S.V., Grams, R. (2015) Bi-functionality of Opisthorchis viverrini aquaporins. Biochimie 108: 149-159. PubMed

 

2014

Krenc, D., Song, J., Almasalmeh, A., Wu, B., Beitz, E. (2014) The arginine-facing amino acid residue of the rat aquaporin 1 constriction determines solute selectivity according to its size and lipophilicity. Mol. Membr. Biol. 31: 228-238. PubMed

Rambow, J., Wu, B., Rönfeldt, D., Beitz, E. (2014) Aquaporins with anion/monocarboxylate permeability: mechanisms, relevance for pathogen-host interactions. Front. Pharmacol. 5: 199. PubMed

Song, J., Mak, E., Wu, B., Beitz, E. (2014) Parasite aquaporins: current developments in drug facilitation and resistance. Biochim. Biophys. Acta 1840: 1566-1573. PubMed

Almasalmeh, A., Krenc, D., Wu, B., Beitz, E. (2014) Structural determinants of the hydrogen peroxide permeability of aquaporins. FEBS J. 281: 647-656. PubMed

FEBS_J Editors' choice article

 

2013

Zeuthen, T., Alsterfjord, M., Beitz, E., MacAulay, N. (2013) Osmotic water transport in aquaporins. Evidence for a stochastic mechanism. J. Physiol. 591: 5017-5029. PubMed

Müller-Lucks, A., Gena, P., Frascaria, D., Altamura, N., Svelto, M., Beitz, E., Calamita, G. (2013) Preparative scale production and functional reconstitution of a human aquaglyceroporin (AQP3) using a cell free expression system. N. Biotechnol. 30: 545-551. PubMed

Krenc, D., Wu, B., Beitz, E. (2013) Specific aquaporins increase the ammonia tolerance of a Saccharomyces cerevisiae mep1-3 fps1 deletion strain. Mol. Membr. Biol. 30: 43-51. PubMed

Seeliger, D., Zapater, C., Krenc, D., Haddoub, R., Flitsch, S., Beitz, E., Cerda, J., de Groot, B.L. (2013) Discovery of novel human aquaporin-1 blockers. ACS Chem. Biol. 8: 249-256. PubMed

 

2012

Altmann, K.S., Havemeyer, A., Beitz, E., Clement, B. (2012) Dimethylarginine-dimethylaminohydrolase-2 (DDAH-2) does not metabolize methylarginines. ChemBioChem 13: 2599-2604. PubMed

Müller-Lucks, A., Bock, S., Wu, B., Beitz, E. (2012) Fluorescent in situ folding control for rapid optimization of cell-free membrane protein synthesis. PLoS One 7: e42186. PubMed

Song, J., Almasalmeh, A., Krenc, D., Beitz, E. (2012) Molar concentrations of sorbitol and polyethylene glycol inhibit the Plasmodium aquaglyceroporin but not that of E. coli: involvement of the channel vestibules. Biochim. Biophys. Acta 1818: 1218-1224. PubMed

von Bülow, J., Müller-Lucks, A., Kai, L., Bernhard, F., Beitz, E. (2012) Functional characterization of a novel aquaporin from Dictyostelium discoideum amoebae implies a unique gating mechanism. J. Biol. Chem. 287: 7487-7494. PubMed

 

2011

Song, J., Wu, B., Beitz, E. (2011) Functional and evolutional implications of natural channel-enzyme fusion proteins. BioMol. Concepts 2: 439- 444. PubMed

Dietz, S., von Bülow, J., Beitz, E., Nehls, U. (2011) The aquaporin gene family of the ectomycorrhizal fungus Laccaria bicolor: lessons for symbiotic functions. New Phytol. 190: 927-940. PubMed

Li, H., Chen, H., Steinbronn, C., Wu, B., Beitz, E., Zeuthen, T., Voth, G.A. (2011) Enhancement of proton conductance by mutations of the selectivity filter of aquaporin-1. J. Mol. Biol. 407: 607-620. PubMed

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Wree, D., Wu, B., Zeuthen, T., Beitz, E. (2011) Requirement for asparagine in the aquaporin NPA signature motifs for cation exclusion. FEBS J. 278: 740-748. PubMed

Geadkaew, A., von Bülow, J., Beitz, E., Grams, S.V., Viyanant, V., Grams, R. (2011) Functional analysis of novel aquaporins from Fasciola gigantica. Mol. Biochem. Parasitol. 175: 144-153. PubMed

Mukhopadhyay, R., Mandal, G., Atluri, V.S.R., Figarella, K., Uzcategui, N.L., Zhou, Y., Beitz, E., Ajees, A.A., Bhattacharjee, H. (2011) The role of alanine 163 in solute permeability of Leishmania major aquaglyceroporin LmAQP1. Mol. Biochem. Parasitol. 175: 83-90. PubMed

 

2010

Wu, B., Song, J., Beitz, E. (2010) Novel channel-enzyme fusion proteins confer arsenate resistance. J. Biol. Chem. 285: 40081-40087. PubMed

Mukhopadhyay, R., Beitz, E. (2010) Metalloid transport by aquaglyceroporins: consequences in the treatment of human diseases. Adv. Exp. Med. Biol. 679: 57-69. PubMed

 

2009

Wu, B., Steinbronn, C., Alsterfjord, M., Zeuthen, T., Beitz, E. (2009) Concerted action of two cation filters in the aquaporin water channel. EMBO J. 28: 2188-2194. PubMed

Aquaporins (2009) Series: Handbook of Experimental Pharmacology, Vol. 190; Beitz, Eric (Ed.) Springer

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Beitz, E., Becker, D., von Bülow, J., Conrad, C., Fricke, N., Geadkaew, A., Krenc, D., Long, H., Song, J., Wree, D., Wu, B. (2009) In vitro analysis and modification of aquaporin pore selectivity. Handb. Exp. Pharmacol. 190: 77-92. PubMed

 

2008

Kotthaus, J., Schade, D., Muschik, N., Beitz, E., Clement, B. (2008) Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: Alkenyl-amidines as new leads. Bioorg. Med. Chem. 16: 10205-10209. PubMed

Kotthaus, J., Schade, D., Töpker-Lehmann, K., Beitz, E., Clement, B. (2008) N(delta)-methylated L-arginine derivatives and their effects on the nitric oxide generating system. Bioorg. Med. Chem. 16: 2305-2312. PubMed

Wu, B., Altmann, K., Barzel, I., Krehan, S., Beitz, E. (2008) A yeast based phenotypic screen for aquaporin inhibitors. Pflügers Arch. - Eur. J. Physiol. 456: 717-720. PubMed

Bahamontes-Rosa, N., Robin, A., Ambrosio, A.R., Messias-Reason, I., Beitz, E., Flitsch, S.L., Kun, J.F.J. (2008) Monoquaternary ammonium derivatives inhibit growth of protozoan parasites. Parasitol. Int. 57: 132-137. PubMed

 

2007

Beitz, E. (2007) Jammed traffic impedes parasite growth. Proc. Natl. Acad. Sci. USA 104: 13855-13856. PubMed

Robin, A., Brown, F., Bahamontes-Rosa, N., Wu, B., Beitz, E., Kun, J.F.J., Flitsch, S.L. (2007) Microwave-assisted ring opening of epoxides: a general route to the synthesis of 1-aminopropan-2-ols with anti malaria parasite activities. J. Med. Chem. 50: 4243-4249. PubMed

Wu, B., Beitz, E. (2007) Aquaporins with selectivity for unconventional permeants. Cell. Mol. Life Sci. 64: 2413-2421. PubMed

Bahamontes-Rosa, N., Wu, B., Beitz, E., Kremsner, P.G., Kun, J.F.J. (2007) Limited genetic diversity of the Plasmodium falciparum aquaglyceroporin gene. Mol. Biochem. Parasitol. 156: 255-257. PubMed

 

2006

Zeuthen, T., Wu, B., Pavlovic-Djuranovic, S., Holm, L.M., Uzcategui, N.L., Duszenko, M., Kun, J.F.J., Schultz, J.E., Beitz, E. (2006) Ammonia permeability of the aquaglyceroporins from Plasmodium falciparum, Toxoplasma gondii and Trypanosoma brucei. Mol. Microbiol. 61: 1598-1608. PubMed

Pavlovic-Djuranovic, S., Kun, J.F.J., Schultz, J.E., Beitz, E. (2006) Dihydroxyacetone and methylglyoxal as permeants of the Plasmodium aquaglyceroporin inhibit parasite proliferation. Biochim. Biophys. Acta 1758: 1012-1017. PubMed

Beitz, E. (2006) Subfamily logos: visualization of sequence deviations at alignment positions with high information content. BMC Bioinformatics 7:313. PubMed

Beitz, E. (2006) Aquaporin water and solute channels from malaria parasites and other pathogenic protozoa. ChemMedChem 1: 587-592. PubMed

Beitz, E., Liu, K., Ikeda, M., Guggino, W.B., Agre, P., Yasui, M. (2006) Determinants of AQP6 trafficking to intracellular sites vs. to the plasma membrane in transfected mammalian cells. Biol. Cell 98: 101-109. PubMed

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Beitz, E., Wu, B., Holm, L.M., Schultz, J.E., Zeuthen, T. (2006) Point mutations in the aromatic/arginine region in aquaporin 1 allow passage of urea, glycerol, ammonia and protons. Proc. Natl. Acad. Sci. USA 103: 269-274. PubMed

 

2005

Beitz, E. (2005) Aquaporins from pathogenic protozoan parasites: structure, function and potential for chemotherapy. Biol. Cell 97: 373-383. PubMed 

 

2004

Uzcategui, N.L., Szallies, A., Pavlovic-Djuranovic, S., Palmada, M., Figarella, K., Boehmer, C., Lang, F., Beitz, E., Duszenko, M. (2004) Cloning, heterologous expression and characterization of three aquaglyceroporins from Trypanosoma brucei. J. Biol. Chem. 279: 42669-42676. PubMed

Beitz, E., Pavlovic-Djuranovic, S., Yasui, M., Agre, P., Schultz, J.E. (2004) Molecular dissection of water and glycerol permeability of the aquaglyceroporin from Plasmodium falciparum by mutational analysis. Proc. Natl. Acad. Sci. USA 101: 1153-1158. PubMed

 

2003

Pavlovic-Djuranovic, S., Schultz, J.E., Beitz, E. (2003) A single aquaporin gene encodes a water/glycerol/urea facilitator in Toxoplasma gondii with similarity to plant tonoplast intrinsic proteins. FEBS Lett. 555: 500-504. PubMed

Beitz, E., Zenner, H.-P., Schultz, J.E. (2003) Aquaporin mediated fluid regulation in the inner ear. Mol. Cell. Neurobiol. 23: 315-329. PubMed

 

2002

Ikeda, M. Beitz, E., Kozono, D., Guggino, W.B., Agre, P., Yasui M. (2002) Characterization of aquaporin-6 as a nitrate channel in mammalian cells: Requirement of pore-lining residue threonine-63. J. Biol. Chem. 277: 39873-39879. PubMed

Hansen, M., Kun, J.F.J., Schultz, J.E., Beitz, E. (2002) A single, bi-functional aquaglyceroporin in blood-stage Plasmodium falciparum malaria parasites. J. Biol. Chem. 277: 4874-4882. PubMed

 

2001

Agre, P., Borgnia, M.J., Yasui, M., Neely, J.D., Carbrey, J., Kozono, D., Beitz, E., Hoffert, J., Leitch, V., King, L.S. (2001) Discovery of the aquaporins and their impact on basic and clinical physiology. Curr. Top. Membr. 51: 1-38.

 

2000

Beitz, E. (2000) TeXtopo: shaded membrane protein topology plots in LaTeX2e. Bioinformatics 16: 1050-1051. PubMed

Beitz, E., Kumagami, H., Ruppersberg, J.P., Schultz, J. E., Agre, P. (2000) The kidney in the inner ear. in Molecular Biology and Physiology of Water and Solute Transport (S. Hohmann and S. Nielsen edts.): 59-62.

Hansen, M., Beitz, E., Schultz, J. E. (2000) An aquaporin gene in Plasmodium falciparum. in Molecular Biology and Physiology of Water and Solute Transport (S. Hohmann and S. Nielsen edts.): 389-392.

Beitz, E. (2000) TeXshade: shading and labeling of multiple sequence alignments using LaTeX2e. Bioinformatics 16: 135-139. PubMed

 

1999

Beitz, E., Kumagami, H., Krippeit-Drews, P., Ruppersberg, J. P., Schultz, J. E. (1999) Expression pattern of aquaporin water channels in the inner ear of the rat. Hearing Res. 132: 76-84. PubMed

Kumagami, H., Beitz, E., Wild, K., Zenner, H.-P., Ruppersberg, J. P., Schultz, J. E. (1999) Expression pattern of adenylyl cyclase isoforms in the inner ear of the rat and immunohistochemical localization of calcineurin in the organ of Corti. Hearing Res. 132: 69-75. PubMed

Beitz, E., Schultz, J. E. (1999) Aquaporine - zelluläre Wasserkanäle als therapeutisches Target? Pharm. u. Z. 28: 67-73. PubMed

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Beitz, E., Schultz, J. E. (1999) The mammalian aquaporin water channel family: a promising new drug target. Curr. Med. Chem. 6: 465-475. PubMed

Seebacher, T., Beitz, E., Kumagami, H., Wild, K., Ruppersberg, J. P., Schultz, J. E. (1999) Expression of membrane-bound and cytosolic guanylyl cyclases in the rat inner ear. Hearing Res.127: 95-102. PubMed

 

1998

Kumagami, H., Loewenheim, H., Beitz, E., Wild, K., Schwartz, H., Yamashita, K., Schultz, J. E., Paysan, J., Zenner, H. P., Ruppersberg, J. P. (1998) The effect of anti-diuretic hormone on the endolymphatic sac of the inner ear. Pflügers Arch. - Eur. J. Physiol.436: 970-975. PubMed

Beitz, E., Völkel, H., Guo, Y., Schultz, J. E. (1998) Adenylyl cyclase type 7 is the predominant isoform in the bovine retinal pigment epithelium. Acta Anat. 162: 157-162. PubMed 

 

1996

Völkel, H., Beitz, E., Klumpp, S., Schultz, J. E. (1996) Cloning and expression of a bovine adenylyl cyclase type VII specific to the retinal pigment epithelium. FEBS Lett. 378: 245-249. PubMed