Christian-Albrechts-Universität zu Kiel

Prof. Dr. Eric Beitz

Neueste Publikationen

Jakobowska, I., Becker, F., Minguzzi, S., Hansen, K., Henke, B., Epalle, N.H., Beitz, E., Hannus, S. (2021) Fluorescence cross-correlation spectroscopy yields true affinity and binding kinetics of Plasmodium lactate transport inhibitors. Pharmaceuticals 14: 757 PubMed

Köpnick, A.L., Geistlinger, K., Beitz, E. (2021) Cysteine 159 delineates a hinge region of the alternating access monocarboxylate transporter 1 and is targeted by cysteine-modifying inhibitors. FEBS J. (Epub ahead of print) PubMed

Beitz, E. (2021) Structure memes: Intuitive visualization of sequence logo and subfamily logo information in a 3D protein-structural context. Proteins 89: 1262-1269. PubMed

Köpnick, A.L., Jansen, A., Geistlinger, K., Epalle, N.H., Beitz, E. (2021) Basigin drives intracellular accumulation of L-lactate by harvesting protons and substrate anions. PLoS One 16: e0249110. PubMed

Schmidt, J.D.R., Walloch, P., Höger, B., Beitz, E. (2021) Aquaporins with lactate/lactic acid permeability at physiological pH conditions. Biochimie 188: 7-11. PubMed

Walloch, P., Hansen, C., Priegann, T., Schade, D., Beitz, E. (2021) Pentafluoro-3-hydroxy-pent-2-en-1-ones potently inhibit FNT-type lactate transporters from all five human-pathogenic Plasmodium species. ChemMedChem 16: 1283-1289. PubMed

Aktuelle Forschungsförderung

- Anti-malarials targeting the plasmodial transketolase and the lactate transporter (TWAS-DFG programme)
- Structure elucidation of the inhibitor-bound plasmodial lactate transporter (DFG)
- Proton transport and proton-coupled transport (EU, Horizon 2020, Marie Skłodowska-Curie Innovative Training Networks)   "PROTON" website

Hauptinteressen der Arbeitsgruppe

Transmembran-Transport von Wasser, Soluten und Metaboliten | Biophysik und Transportmechanismen | Molekulare Regulation, Selektivitätsmechanismen und Inhibition von Aquaporinen und Metabolit-Transportern aus Mensch und pathogenen Parasiten | Evaluation von Wirkstoff-Targets  | Inhibitor-Screening, -Design und -Synthese