Publikationen

2020

[38] Lunk I, Litty F-A, Hennig S, Vetter IR, Kotthaus J, Altmann KS, Ott G, Havemeyer A, Carrillo García C, Clement B, Schade D* "Discovery of N-(4-Aminobutyl)-N’-(2-Methoxyethyl)guanidine as the First Selective, Non-Amino Acid, Catalytic Site Inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1)" Journal of Medicinal Chemistry 2020, 63(1), 425-432 [link]

[37] Barth ER, Längle D, Wesseler F, Golz C, Krupp A, Schade D, Strohmann C* "Higher carbon analogues of 1,4-dihydropyridines as potent TGFβ/Smad inhibitors" European Journal of Inorganic Chemistry 2020, 176-181 [link]

2019

[36] Halver J, Wenzel K, Sendker J, Carrillo Garcia C, Erdelmeier CAJ, Willems E, Mercola M, Symma M, Könemann S, Koch E, Hensel A, Schade D* "Crataegus Extract WS®1442 Stimulates Cardiomyogenesis and Angiogenesis From Stem Cells: A Possible New Pharmacology for Hawthorn?" Frontiers in Pharmacology 2019, 10, 1357, doi: 10.3389/fphar.2019.01357  [link]

[35] Längle D, Wesseler F, Flötgen D, Leek H, Plowright AT, Schade D* "Unique photoaffinity probes to study TGFβ signaling and receptor fates" Chemical Communications 2019, 55, 4323-4326 [link]

[34] Vojacek S, Schulig L, Wössner N, Geist N, Langel W, Jung M, Schade D, Link A "Tetrahydroindoles as Multipurpose Screening Compounds and
Novel Sirtuin Inhibitors" ChemMedChem 2019, 14, 853-864 [link]

[33] Längle D, Werner TR, Wesseler F, Reckzeh E, Schaumann N, Drowley L, Polla M, Plowright AT, Hirt MN, Eschenhagen T, Schade D* "Toward Second-Generation Cardiomyogenic and Anti-cardiofibrotic 1,4-Dihydropyridine-Class of TGFβ Inhibitors” ChemMedChem 2019, 14, 810-822 [link]

[link]

 

2018

[32] García-Reyes, B; Witt, L; Jansen, B; Karasu, E; Gehring, T; Leban, J; Henne-Bruns, D; Pichlo, C; Brunstein, E; Baumann, U; Wesseler, F; Rathmer, B; Schade D; Peifer, C*; Knippschild, U* "Discovery of IWP-2 and related compounds as selective ATP-competitive inhibitors of CK1δ/e" Journal of Medicinal Chemistry 2018, 61(9), 4087-4102 [link]

[31] Brand S, Roy S, Schröder P, Rathmer B, Roos J, Kapoor S, Patil S, Pommerenke C, Maier T, Janning P, Steinhilber D, Schade D, Schneider G, Kumar K, Ziegler S, Waldmann H* "Combined proteomic and in silico target identification reveal a new role for 5-lipoxygenase in developmental signaling pathways" Cell Chemical Biology 2018, 25(9), 1095-1106  [link]

2017

[30] Dietrich L, Rathmer B, Ewan K, Bange T, Heinrichs S, Dale TC, Schade D, Grossmann TN* "Cell Permeable Stapled Peptide Inhibitor of Wnt Signaling That Targets β-Catenin Protein-Protein Interactions" Cell Chemical Biology 2017, 24(8), 958-968 [link]

[29] Breckwoldt K, Letuffe-Brenière D, Mannhardt I, Schulze T, Ulmer B, Werner T, Benzin A, Klampe B, Reinsch MC, Laufer S, Shibamiya A, Prondzynski M, Mearini G, Schade D, Fuchs S, Neuber C, Krämer E, Saleem U, Schulze ML, Rodriguez ML, Eschenhagen T,* Hansen A* "Generation of Human Engineered Heart Tissue" Nature Protocols 2017, 11(6), 1177-1197 [link]

2016

[28] Litty F-A, Gudd, J, Girreser U, Clement B, Schade D* "Design, Synthesis and Bioactivation of O‑Glycosylated Prodrugs of the Natural Nitric Oxide-Precursor Nω-Hydroxy-L-Arginine" Journal of Medicinal Chemistry 2016, 59(17):8030-41 [link]

[27] Hoffmann A, Schade D, Kirchmair J, Clement B, Sauerbrei A, Schmidtke M* "Resistance determinants of an orally bioavailable 5-amidino analog of oseltamivir and their impact on viral fitness - A reverse genetics study in the influenza virus N1 background" Journal of Virological Methods 2016, 237:192-199 [link]

[26] Litty F-A, Girreser U, Clement B, Schade D* "Efficient Synthesis of Optically Pure Nδ‑Monomethylated L-Arginine and L-Ornithine" Synthesis 2016, 48, A-G [link]
Highlighted in Thieme Chemistry SYNFORM 2016 [link]

[25] Rao J, Pfeiffer M, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel S, Schöler H, Seebohm G, Greber B* "Stepwise clearance of repressive roadblocks drives cardiac induction in human ES cells" Cell Stem Cell 2016, 18(3), 341-453   [link]

2015

[24] Halver J, Carrillo-Garcia C, Willems E, Schade D* "Crataegus ssp. promotes late-stage cardiac differentiation and regeneration" Planta Medica 2015, 81(16), PW61

[23] Schade D* "A phytomedicine approach to stem cell modulation for heart regeneration" Planta Medica 2015, 81(16), SL2B_03

[22] Schade D*, Plowright A T "Medicinal Chemistry Approaches to Heart Regeneration" Journal of Medicinal Chemistry 2015, 58(24): 9451-9479 [link]

[21] Schade D*, Hansen A, Greber B* "Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: Generation, Properties and Applications in Drug Discovery and Development" Drug Target Review 2015 2(2), 34-38 (Invited Mini-Review) [link] 

[20] Schade D, Kotthaus J, Riebling L, Kotthaus J, Müller-Fielitz H, Raasch W, Hoffmann A, Schmidtke M, Clement B* "Zanamivir Amidoxime- and N-Hydroxyguanidine-Based Prodrug Approaches to Tackle Poor Oral Bioavailability" Journal of Pharmaceutical Sciences 2015, 104(9): 3208-3219 [link]

[19] Längle D, Marquardt V, Heider E, Vigante B, Duburs G, Luntena I, Flötgen D, Golz C; Strohmann C, Koch O, Schade D* "Design, synthesis and 3D-QSAR studies of novel 1,4-dihydropyridines as TGFβ/Smad inhibitors" European Journal of Medicinal Chemistry 2015, 95: 249-266 [link]

2014

[18] Schade D*, Kotthaus J, Riebling L, Kotthaus J, Müller-Fielitz H-M, Raasch W, Koch O, Seidel N, Schmidtke M, Clement B "Development of novel potent orally bioavailable oseltamivir derivatives active against resistant influenza A" Journal of Medicinal Chemistry 2014, 57(3): 759-769 [link]

[17] Längle D, Halver J, Rathmer B, Willems E, Schade D* "Small Molecules Targeting in Vivo Tissue Regeneration" ACS Chemical Biology 2014, 9(1): 57-71[link]

2012

[16] Schade D*, Lanier M, Willems E*, Okolotowicz K, Gilley C, Mercola M, Cashman J "Synthesis and SAR of novel cardiomyogenic b-annulated 1,4-dihydropyridines as inhibitors of TGFß signaling" Journal of Medicinal Chemistry 2012, 55(22): 9946-9957 (co-first with ML) [link]

[15] Willems E*, Teixeira JC, Schade D, Reeves P, Bushway PJ, Lanier M, Wenqing C, Walsh C, Kirchhausen T, Izpisúa-Belmonte JC, Cashman J, Mercola M* "Small molecule-mediated TGFß Type II receptor degradation promotes cardiomyogenesis in embryonic stem cells" Cell Stem Cell 2012, 11(2): 242-252 [link]

[14] Lanier M*,Schade D, Willems E, Tsuda M, Spiering S, Kalisiak J, Mercola M, Cashman JR "Wnt inhibition correlates with human cardiogenesis: An embryonic stem cell SAR study based on IWR-1 analogs", Journal of Medicinal Chemistry 2012, 55(2): 697-708 (co-first authorship with ML) [link]

[13] Kotthaus J, Schade D, Lunk I, Kotthaus J, Muschick N, Clement B* "Designing Modulators of Dimethylarginine Dimethylaminohydrolase (DDAH) – A Focus on Selectivity over Arginase", The Journal of Enzyme Inhibition and Medicinal Chemistry 2012, 27(1): 24-28 [link]

2011

[12] Kotthaus J, Kotthaus J, Schade D, Schwering U, Hungeling H, Müller-Filietz H, Raasch W, Clement B* "New prodrugs of the antiprotozoal drug pentamidine", ChemMedChem 2011, 6(12): 2233-2242 [link]

[11] Schade D*, Kotthaus J, Kotthaus J, Muschick N, Clement B* "Prodrug design for the potent cardiovascular agent Nω hydroxy-L-arginine: Synthetic approaches and physicochemical characterization", Organic and Biomolecular Chemistry 2011, 9(14): 5249-5259 [link]

[10] Kotthaus J, Hungeling H, Kotthaus J, Schade D, Reeh C, Grünewald S, Kunze T, Wein S, Wolffram S, Clement B* "Synthesis and biological evaluation of L valine amidoximeesters as double prodrugs of amidines" Bioorganic and Medicinal Chemistry 2011, 19: 1907-1914[link]

[9] Kotthaus J, Wahl B, Kotthaus J, Schade D, Grünewald S, Bittner F, Mendel R, Clement B* "Involvement of the mitochondrial amidoxime reducing components (mARCs) in the reduction of Nω hydroxy-L-arginines." Biochemical Journal 2011, 433(2): 383-391 [link]

2010

[8] Schade D*, Kotthaus J, Clement B "Modulating the NO-Generating System from a Medicinal Chemistry Perspective: Current Trends and Therapeutic Options" Pharmacology and Therapeutics 2010, 126: 279-300 [link]

[7] Kotthaus J, Steinmetzer T, Kotthaus J, Schade D, van de Locht A, Clement B* "Metabolism and distribution of two highly potent and selective peptidomimetic inhibitors of matriptase", Xenobiotica 2010, 40 (2): 93-101[link]

[6] Schröder A, Kotthaus J, Schade D, Clement B, Rehse K* "Arylazoamidoximes and Related Compounds as NO-modulators" Archiv der Pharmazie 2010, 343: 9-16 [link]

2009

[5] Schade D, Kotthaus J, Hungeling H, Clement B* "The peptidyl-glycine α-amidating monooxygenase (PAM): A novel prodrug-strategy for amidoximes and hydroxyguanidines." ChemMedChem 2009, 4 (10): 1595-1599 [link]

2008

[4] Kotthaus, J.; Schade D.; Muschick, N.; Beitz, E.; Clement, B.* "Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads." Bioorganic and Medicinal Chemistry 2008, 16 (24), 10205-10209 [link]

[3] Kotthaus, J.; Schade D.; Töpker-Lehmann, K.; Beitz, E.; Clement, B.* "Nδ-Methylated L arginine derivatives and their effects on the nitric oxide generating system." Bioorganic and Medicinal Chemistry 2008, 16 (5), 2305-2012[link]

[2] Schade D.; Kotthaus, J.; Clement, B.* "Efficient synthesis of optically pure Nw alkylated L arginines." Synthesis 2008, 15, 2391-2397[link]

[1] Schade D.; Töpker-Lehmann, K.; Kotthaus, J.; Clement, B.* "Synthetic approaches to "Nω -methylated L arginine, Nδ-hydroxy-L-arginine, L citrulline, and Nδ-cyano-L-ornithine." The Journal of Organic Chemistry 2008, 73 (3), 1025-1030 [link]